Publication Date:
1984-01-20
Description:
Low levels of cerebral concussion in the cat produce reversible behavioral suppression presumably associated with unconsciousness. This injury is also associated with increased rates of glucose utilization in regions within the dorsomedial pontine tegmentum. Microinjection of carbachol into these regions produced behavioral suppression resembling that following concussion. These data, together with previously published observations on cholinergic responses to brain injury, suggest that concussive unconsciousness may be attributable in part to activation of cholinergic pontine sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hayes, R L -- Pechura, C M -- Katayama, Y -- Povlishock, J T -- Giebel, M L -- Becker, D P -- NS 12587/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701514" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Atropine/pharmacology
;
Brain Concussion/*physiopathology
;
Carbachol/pharmacology
;
Cats
;
Cholinergic Fibers/*physiopathology
;
Deoxyglucose/metabolism
;
Pons/metabolism/*physiopathology
;
Tetracaine/pharmacology
;
Unconsciousness/*physiopathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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