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  • 1
    Publikationsdatum: 2023-12-21
    Beschreibung: The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies.
    Schlagwort(e): R5-920 ; RC581-607 ; cytoskeleton dynamics ; intracellular signalling ; Immunological Synapse ; endosomal dynamics ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    facet.materialart.
    Unbekannt
    FrancoAngeli | Transizioni = Transitions
    Publikationsdatum: 2024-03-23
    Beschreibung: The volume, dedicated to the 44th International Conference of the Italian Union for Drawing, investigates the theme of ‘Transitions’, which particularly effectively represents our time and the current condition of the discipline of Drawing. The term, beyond its generic meaning of an intermediate stage in a process in which a condition changes from one state to another, has always been used in various fields, from music to geophysics. In fact, the disciplines of drawing have always been confronted with themes and issues relating to transitions from one condition to another. The history of representation tells us of transformations, even epochal ones, relating to ‘drawing’, with all that such transitions entail: suffice it to think of the evolution of forms of representation, of instrumental apparatuses, of the mutability of supports, of the analogical-digital transition underway, of the new modes of communication on platforms, of the hypertrophic offer of images also on the net that confirms Guy Debord’s intuitions relating to the new spectacularisation of society. Similarly, representation triggers transitions in the prefiguration and communication of design, the anticipation and foreshadowing of future events.The challenges posed by the digital pose open questions whose scope can only be glimpsed, such as the relationship between drawing and the act of modelling, and the construction of new paradigms of visual language and communication. ‘Transitions’, almost implicitly, points to possible futures, the evolution of technique and the search for new modes of expression; at the same time, however, it can suggest silences and reflections in a process of connection between history, theory, criticism and construction.
    Schlagwort(e): Transitions ; Cross ; Modulate ; Develop ; Drawing ; Science of Representation ; thema EDItEUR::A The Arts::AM Architecture::AMC Architectural structure and design ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBG Engineering graphics and draughting / technical drawing ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGZ The Arts: techniques and principles
    Sprache: Italienisch , Englisch , Spanisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2024-04-01
    Beschreibung: The considerable number of viral infectious disease threats that have emerged since the beginning of the 21st century have shown the need to dispose global and coordinated responses to fight properly and efficiently against them. Severe acute respiratory syndrome (2003), avian influenza in humans (2005), A(H1N1) pandemic influenza (2009), Middle East respiratory syndrome coronavirus (MERS-CoV) (2012 onward) and Ebola virus disease (2014-2015) are some of the most important examples. The latest emerging and devastating threat was Zika virus, an arbovirus that provoked more than 500,000 suspicious cases in the Americas in 2016 and notable processes of social and medical alarms due to the evidence of a causal link between Zika virus and several congenital injuries, like microcephaly, as well as due to its association with neurological disorders such as Guillain-Barré syndrome in adults (PAHO, 2017). In the framework of this global response and multistrategic approach, the purpose of this Research Topic is to provide updated information and novel researches about control strategies, encompassing virological, entomological and epidemiological data, in order to reach the triad of protagonists of transmission cycles (virus, mosquitoes and humans).
    Schlagwort(e): RC346-429 ; R5-920 ; RA1-1270 ; QR1-502 ; Q1-390 ; RC109-216 ; Public Health ; Mosquitoes ; Zika virus ; Arbovirus ; Microcephaly ; Epidemiology ; Flavivirus ; Guillain-Barre Syndrome ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    facet.materialart.
    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-12-21
    Beschreibung: Marine biotoxins may pose a threat to the human consumption of seafood and seafood products. The increasing global trade and higher demand for seafood products worldwide represents a challenge for food safety authorities, policy makers, food business operators, and the scientific community, in particular, researchers devoted to environmental sciences, toxicology, and analytical chemistry. In addition, due to changes in climate conditions and technological developments, new and emerging marine toxins are being detected in regions where they were previously unknown. This Special Issue highlight studies aiming to the develop detection methods for marine biotoxins for better understanding the dynamics of accumulation/elimination of marine biotoxins and their effects on marine organisms, as well as toxin exposure studies that aim to evaluate the risks associated with the consumption of contaminated seafood.
    Schlagwort(e): R5-920 ; RA1190-1270 ; mass mortality ; marine biotoxin ; n/a ; alamethicin ; synergy ; seafood toxin ; patulin ; Paralytic shellfish toxin ; greater blue-ringed octopus ; Alexandrium catenella ; paralytic toxicity ; Ishigaki Island ; depuration ; okadaic acid ; serum biomarker ; ecotoxicological responses ; Hapalochlaena lunulata ; sydowinin A ; purification ; PSP outbreak ; southern Chile ; posterior salivary gland ; saxitoxin ; harmful algal blooms ; gliotoxin ; seafood safety ; uptake ; immunoaffinity column ; Alexandrium ; sydowinol ; chronic exposure ; environmental neurotoxin ; assimilation ; shellfish ; LC-MS ; biotransformation ; Perna viridis ; domoic acid ; fish ; algal toxin ; warming ; tetrodotoxin ; Mesodesma donacium ; combination index ; ultrahigh high performance liquid chromatography tandem mass spectrometry ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
    Format: application/octet-stream
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 2024-03-23
    Beschreibung: The volume, dedicated to the 44th International Conference of the Italian Union for Drawing, investigates the theme of ‘Transitions’, which particularly effectively represents our time and the current condition of the discipline of Drawing. The term, beyond its generic meaning of an intermediate stage in a process in which a condition changes from one state to another, has always been used in various fields, from music to geophysics. In fact, the disciplines of drawing have always been confronted with themes and issues relating to transitions from one condition to another. The history of representation tells us of transformations, even epochal ones, relating to ‘drawing’, with all that such transitions entail: suffice it to think of the evolution of forms of representation, of instrumental apparatuses, of the mutability of supports, of the analogical-digital transition underway, of the new modes of communication on platforms, of the hypertrophic offer of images also on the net that confirms Guy Debord’s intuitions relating to the new spectacularisation of society. Similarly, representation triggers transitions in the prefiguration and communication of design, the anticipation and foreshadowing of future events.The challenges posed by the digital pose open questions whose scope can only be glimpsed, such as the relationship between drawing and the act of modelling, and the construction of new paradigms of visual language and communication. ‘Transitions’, almost implicitly, points to possible futures, the evolution of technique and the search for new modes of expression; at the same time, however, it can suggest silences and reflections in a process of connection between history, theory, criticism and construction.
    Schlagwort(e): Transitions ; Cross ; Modulate ; Develop ; Drawing ; Science of Representation ; thema EDItEUR::A The Arts::AM Architecture::AMC Architectural structure and design ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBG Engineering graphics and draughting / technical drawing ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGZ The Arts: techniques and principles
    Sprache: Italienisch , Englisch , Spanisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 6
    Publikationsdatum: 2024-03-23
    Beschreibung: The volume, dedicated to the 44th International Conference of the Italian Union for Drawing, investigates the theme of ‘Transitions’, which particularly effectively represents our time and the current condition of the discipline of Drawing. The term, beyond its generic meaning of an intermediate stage in a process in which a condition changes from one state to another, has always been used in various fields, from music to geophysics. In fact, the disciplines of drawing have always been confronted with themes and issues relating to transitions from one condition to another. The history of representation tells us of transformations, even epochal ones, relating to ‘drawing’, with all that such transitions entail: suffice it to think of the evolution of forms of representation, of instrumental apparatuses, of the mutability of supports, of the analogical-digital transition underway, of the new modes of communication on platforms, of the hypertrophic offer of images also on the net that confirms Guy Debord’s intuitions relating to the new spectacularisation of society. Similarly, representation triggers transitions in the prefiguration and communication of design, the anticipation and foreshadowing of future events.The challenges posed by the digital pose open questions whose scope can only be glimpsed, such as the relationship between drawing and the act of modelling, and the construction of new paradigms of visual language and communication. ‘Transitions’, almost implicitly, points to possible futures, the evolution of technique and the search for new modes of expression; at the same time, however, it can suggest silences and reflections in a process of connection between history, theory, criticism and construction.
    Schlagwort(e): Transitions ; Cross ; Modulate ; Develop ; Drawing ; Science of Representation ; thema EDItEUR::A The Arts::AM Architecture::AMC Architectural structure and design ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBG Engineering graphics and draughting / technical drawing ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGZ The Arts: techniques and principles
    Sprache: Italienisch , Englisch , Spanisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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