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  • 1
    Electronic Resource
    Electronic Resource
    Generation of two isomers with the same disulfide connectivity during disulfide bond formation of human uroguanylin (1996)
    Springer
    International journal of peptide research and therapeutics 3 (1996), S. 45-52 
    Details
    ISSN: 1573-3904
    Keywords: Biological activity ; Isomer ratio ; RP-HPLC analysis ; Topological isomer ; Two-step disulfide bond formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary In a two-step selective disulfide-bond-forming reaction of human uroguanylin, a 16-residue peptide with two intramolecular disulfide bonds, two compounds (I and II) were formed, which could be detected by RP-HPLC after the second disulfide-bond-forming reaction and were isolated as single entities. Their primary structures, molecular weights, and disulfide connectivities proved to be identical, but their optical rotation values were different, suggesting that they are topological isomers. Only compound I was found to increase the cGMP levels in cultured T84 cells significantly. The ratio of these compounds was affected by the order of the disulfide-bond-forming reactions, but not by the solvent used. The presence of a carboxyl-terminal leucine residue seems to be crucial for stabilizing the conformation of the two isomers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00131085
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  • 2
    Electronic Resource
    Electronic Resource
    Chicken atrial natriuretic peptide (chANP) and its secretion (1990)
    Springer
    Cell & tissue research 259 (1990), S. 293-298 
    Details
    ISSN: 1432-0878
    Keywords: Atrial natriuretic peptide (ANP) ; Chicken natriuretic peptide (chANP) ; Atrial-specific granule ; Sarcoplasmic reticulum ; Immunohistochemistry ; Domestic fowl (Aves, Phasianiformes)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An immunohistochemical study using antiserum raised against synthetic chicken natriuretic polypeptide was used to investigate the distribution of this peptide in the chicken heart. Immunoreactive cells, both in the atrial and ventricular walls, were identified by electron microscopy, and electron-dense granules in the atrial and ventricular cardiocytes were revealed to be storage sites of the peptide. The electron-dense material, thought to be the peptide, was found in the sarcoplasmic reticulum, and it is suggested that a secretory pathway of the peptide through the latter to extracellular space, may be present, in addition to an exocytotic one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318451
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    Paper (German National Licenses)
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