Publikationsdatum:
2009-04-04
Beschreibung:
Sleep is universal, strictly regulated, and necessary for cognition. Why this is so remains a mystery, although recent work suggests that sleep, memory, and plasticity are linked. However, little is known about how wakefulness and sleep affect synapses. Using Western blots and confocal microscopy in Drosophila, we found that protein levels of key components of central synapses were high after waking and low after sleep. These changes were related to behavioral state rather than time of day and occurred in all major areas of the Drosophila brain. The decrease of synaptic markers during sleep was progressive, and sleep was necessary for their decline. Thus, sleep may be involved in maintaining synaptic homeostasis altered by waking activities.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715914/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715914/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilestro, Giorgio F -- Tononi, Giulio -- Cirelli, Chiara -- DP1 OD000579/OD/NIH HHS/ -- DP1 OD000579-01/OD/NIH HHS/ -- DP1 OD000579-02/OD/NIH HHS/ -- DP1 OD000579-03/OD/NIH HHS/ -- DP1 OD000579-04/OD/NIH HHS/ -- R01 GM075315/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2009 Apr 3;324(5923):109-12. doi: 10.1126/science.1166673.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19342593" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Biological Clocks
;
Blotting, Western
;
Brain/physiology
;
Circadian Rhythm
;
Drosophila Proteins/*metabolism
;
Drosophila melanogaster/*physiology
;
Female
;
Homeostasis
;
Male
;
Microscopy, Confocal
;
Models, Animal
;
Qa-SNARE Proteins/metabolism
;
Sleep/*physiology
;
Sleep Deprivation
;
Synapses/*physiology
;
Synapsins/metabolism
;
Tumor Suppressor Proteins/metabolism
;
Wakefulness/*physiology
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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