ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Spacecraft Propulsion and Power  (3)
  • Osteoclasts  (2)
Collection
Keywords
Publisher
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 34 (1982), S. 422-427 
    ISSN: 1432-0827
    Keywords: Osteoclasts ; Osteopetrosis ; Autoradiography ; Cell kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Excessive skeletal mass and reduced bone resorption characteristic of osteopetrosis in youngia rats can be corrected by irradiation and transfer of spleen cells from normal littermates. Cell population analyses and3H-thymidine (3H-TdR) autoradiographic methods were used to determine osteoclast population dynamics and kinetics of incorporation of nuclei following whole-body irradiation and spleen cell transfer inia/ia rats and in untreatedia rats and their (ia/+) normal littermates. The numbers of osteoclasts per metaphyseal area were greater inia rats than in (ia/+) normal littermates. Untreatedia rats had greater rates of incorporation of3H-TdR-labeled nuclei into osteoclasts but were reduced to near normal values following irradiation and spleen cell transfer. Labeled osteoclast nuclei were first seen in the primary spongiosa of the femoral metaphysis and with increasing time appeared at greater distances from the epiphyseal growth plate as the bones grew in length. These sites of osteoclast neogenesis correspond to sites where restoration of bone resorption is initially seen following bone marrow and splenic transplants in the treatment of osteopetrosis.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-0827
    Keywords: Diphosphonate ; Bone ; Osteoclasts ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Male rats weighing 100 g were injected with vehicle (control group), 0.4 or 4.0 mg/kg/day of ethane-1-hydroxy-1,1-diphosphonate (EHDP). Beginning after 6 days of EHDP treatment all rats received six subcutaneous injections of3H-thymidine at 8 h intervals. The multiple labeling index of autoradiographically defined labeled cells was determined for the osteoprogenitor cells of the primary spongiosa of the proximal tibial metaphysis. The osteoclasts in the proximal tibial metaphysis were assayed for population parameters and incorporation of labeled nuclei at sequential intervals after the administration of3H-thymidine. After 6 days of EHDP pre-treatment the multiple labeling index of the osteoprogenitor cells was reduced with 4.0 mg/kg/day dose of EHDP. At the beginning of the experimental kinetic sampling period, after the 6 days of EHDP pre-treatment, EHDP treatment resulted in significant increases in the numbers of osteoclasts, nuclei per osteoclast profile, and total osteoclast nuclei. During the sampling period, the 4.0 mg/kg/day dose of EHDP caused further increases in the number of total osteoclasts. EHDP treatment caused a marked increase in the rate of incorporation and accumulation of3H-thymidine-labeled nuclei in osteoclasts. Thus, EHDP causes an accelerated rate of osteoclast production from precursor cells in spite of its ability to slow bone resorption. Although the origin of osteoclast nuclei is not clear, the kinetic data from this study suggests that osteoclast nuclei are not arising from osteoprogenitor cells or osteocytes in the EHDP-treated animals.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2019-07-19
    Description: Component performance assessment testing for a, pressure-fed earth storable bipropellant rocket engine was successfully completed at Aerojet's Redmond test facility. The primary goal of the this development project is to increase the specific impulse of an apogee class bi-propellant engine to greater than 330 seconds with nitrogen tetroxide and monomethylhydrazine propellants and greater than 335 seconds with nitrogen tetroxide and hydrazine. The secondary goal of the project is to take greater advantage of the high temperature capabilities of iridium/rhenium chambers. In order to achieve these goals, the propellant feed pressures were increased to 400 psia, nominal, which in turn increased the chamber pressure and temperature, allowing for higher c*. The tests article used a 24-on-24 unlike doublet injector design coupled with a copper heat sink chamber to simulate a flight configuration combustion chamber. The injector is designed to produce a nominal 200 lbf of thrust with a specific impulse of 335 seconds (using hydrazine fuel). Effect of Chamber length on engine C* performance was evaluated with the use of modular, bolt-together test hardware and removable chamber inserts. Multiple short duration firings were performed to characterize injector performance across a range of thrust levels, 180 to 220 lbf, and mixture ratios, from 1.1 to 1.3. During firing, ignition transient, chamber pressure, and various temperatures were measured in order to evaluate the performance of the engine and characterize the thermal conditions. The tests successfully demonstrated the stable operation and performance potential of a full scale engine with a measured c* of XXXX ft/sec (XXXX m/s) under nominal operational conditions.
    Keywords: Spacecraft Propulsion and Power
    Type: 44th AIAA/ASME/SAE/ASEE Joint Propulsion Conference and Exhibit; Jul 20, 2008 - Jul 23, 2008; Hartford, CT; United States
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2019-10-24
    Description: The next phase of robotic and human deep space exploration missions requires high performance, high power solar electric propulsion systems for large-scale science missions and cargo transportation. Aerojet Rocketdyne's Advanced Electric Propulsion System (AEPS) program is completing development and qualification of a 13kW flight EP system to support NASA exploration. The first use of the AEPS is planned for the NASA Power & Propulsion Element, which is the first element of NASA's cis-lunar Gateway. The flight AEPS system includes a magnetically shielded long-life Hall thruster, power processing unit (PPU), and xenon flow controller (XFC). The Hall thruster, originally developed and demonstrated by NASA's Glenn Research Center and the Jet Propulsion Laboratory, operates at input powers up to 13.3kW while providing a specific impulse over 2600s at an input voltage of 600V. The power processor is designed to accommodate an input voltage range of 95 to 140V, consistent with operation beyond the orbit of Mars. The integrated system is continuously throttleable between 3 and 13.3kW. The program has completed testing of the Technology Development Units and is progressing into the Engineering Development Unit test phase and the final design phase to Critical Design Review (CDR). This paper will present the high power AEPS system capabilities, overall program and design status and the latest test results for the 13kW flight system development as well as the plans for the development and qualification effort of the EP string.
    Keywords: Spacecraft Propulsion and Power
    Type: GRC-E-DAA-TN72874 , 2019 International Electric Propulsion Confernce; Sep 15, 2019 - Sep 20, 2019; Vienna; Austria
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2019-07-13
    Description: This paper summarizes the work performed to dale on the NASA Cycle 3A Advanced Chemical Propulsion Technology Program. The primary goals of the program are to design, fabricate, and test high performance bipropellant engines using iridium/rhenium chamber technology to obtain 335 seconds specific impulse with nitrogen tetroxide/hydrazine propellants and 330 seconds specific impulse with nitrogen tetroxide/monomethylhydrazine propellants. Aerojet has successfully completed the Base Period of this program, wherein (1) mission and system studies have been performed to verify system performance benefits and to determine engine physical and operating parameters, (2) preliminary chamber and nozzle designs have been completed and a chamber supplier has been downselected, (3) high temperature, high pressure off-nominal hot fire testing of an existing state-of-the-art high performance bipropellant engine has been completed, and (4) thermal and performance data from the engine test have been correlated with new thermal models to enable design of the new engine injector and injector/chamber interface. In the next phase of the program, Aerojet will complete design, fabrication, and test of the nitrogen tetroxide/hydrazine engine to demonstrate 335 seconds specific impulse, and also investigate improved technologies for iridium/rhenium chamber fabrication. Achievement of the NRA goals will significantly benefit NASA interplanetary missions and other government and commercial opportunities by enabling reduced launch weight and/or increased payload. At the conclusion of the program, the objective is to have an engine ready for final design and qualification for a specific science mission or commercial application. The program also constitutes a stepping stone to future, development, such as higher pressure pump-fed in-space storable engines.
    Keywords: Spacecraft Propulsion and Power
    Type: NASA Science and Technology Conference (NSTC); Jun 19, 2007 - Jun 21, 2007; College Park, MD; United States
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...