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  • 1
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    Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-04-11
    Description: Aneuploidy, the inheritance of an atypical chromosome complement, is common in early human development and is the primary cause of pregnancy loss. By screening day-3 embryos during in vitro fertilization cycles, we identified an association between aneuploidy of putative mitotic origin and linked genetic variants on chromosome 4 of maternal genomes. This associated region contains a candidate gene, Polo-like kinase 4 (PLK4), that plays a well-characterized role in centriole duplication and has the ability to alter mitotic fidelity upon minor dysregulation. Mothers with the high-risk genotypes contributed fewer embryos for testing at day 5, suggesting that their embryos are less likely to survive to blastocyst formation. The associated region coincides with a signature of a selective sweep in ancient humans, suggesting that the causal variant was either the target of selection or hitchhiked to substantial frequency.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCoy, Rajiv C -- Demko, Zachary -- Ryan, Allison -- Banjevic, Milena -- Hill, Matthew -- Sigurjonsson, Styrmir -- Rabinowitz, Matthew -- Fraser, Hunter B -- Petrov, Dmitri A -- R01 GM089926/GM/NIGMS NIH HHS/ -- R01 GM097415/GM/NIGMS NIH HHS/ -- R01 GM100366/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2015 Apr 10;348(6231):235-8. doi: 10.1126/science.aaa3337.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Stanford University, Stanford, CA, USA. ; Natera, Inc., San Carlos, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25859044" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; *Aneuploidy ; Blastomeres ; Embryo, Mammalian/*physiology ; Embryonic Development ; Fathers ; Female ; Fertilization in Vitro ; Genetic Association Studies ; Genetic Testing ; Haplotypes ; Humans ; Male ; *Mitosis ; Mothers ; Phenotype ; *Polymorphism, Single Nucleotide ; Protein-Serine-Threonine Kinases/*genetics/physiology ; Selection, Genetic ; Trophoblasts
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Overview 2004 of NASA-Stirling Convertor CFD Model Development and Regenerator R and D Efforts (2004)
    In:  CASI
    Details
    Publication Date: 2019-08-15
    Description: This paper reports on accomplishments in 2004 in (1) development of Stirling-convertor CFD models at NASA Glenn and via a NASA grant, (2) a Stirling regenerator-research effort being conducted via a NASA grant (a follow-on effort to an earlier DOE contract), and (3) a regenerator-microfabrication contract for development of a "next-generation Stirling regenerator." Cleveland State University is the lead organization for all three grant/contractual efforts, with the University of Minnesota and Gedeon Associates as subcontractors. Also, the Stirling Technology Company and Sunpower, Inc. are both involved in all three efforts, either as funded or unfunded participants. International Mezzo Technologies of Baton Rouge, Louisiana is the regenerator fabricator for the regenerator-microfabrication contract. Results of the efforts in these three areas are summarized.
    Keywords: Spacecraft Propulsion and Power
    Type: NASA/TM-2004-213404 , E-14912 , Space Technology and Applications International Forum; Feb 13, 2005 - Feb 17, 2005; Albuquerque, NM; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Stirling Analysis Comparison of Commercial Versus High-Order Methods (2005)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Recently, three-dimensional Stirling engine simulations have been accomplished utilizing commercial Computational Fluid Dynamics software. The validations reported can be somewhat inconclusive due to the lack of precise time accurate experimental results from engines, export control/proprietary concerns, and the lack of variation in the methods utilized. The last issue may be addressed by solving the same flow problem with alternate methods. In this work, a comprehensive examination of the methods utilized in the commercial codes is compared with more recently developed high-order methods. Specifically, Lele's compact scheme and Dyson's Ultra Hi-Fi method will be compared with the SIMPLE and PISO methods currently employed in CFD-ACE, FLUENT, CFX, and STAR-CD (all commercial codes which can in theory solve a three-dimensional Stirling model with sliding interfaces and their moving grids limit the effective time accuracy). We will initially look at one-dimensional flows since the current standard practice is to design and optimize Stirling engines with empirically corrected friction and heat transfer coefficients in an overall one-dimensional model. This comparison provides an idea of the range in which commercial CFD software for modeling Stirling engines may be expected to provide accurate results. In addition, this work provides a framework for improving current one-dimensional analysis codes.
    Keywords: Spacecraft Propulsion and Power
    Type: NASA/TM-2005-213976 , AIAA Paper 2005-5580 , E-15295 , Third International Energy Conversion Engineering Conference; Aug 15, 2005 - Aug 18, 2005; San Francisco, California; United States
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    NASA TECHNICAL REPORTS
  • 4
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    On the Need for Multidimensional Stirling Simulations (2005)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Given the cost and complication of simulating Stirling convertors, do we really need multidimensional modeling when one-dimensional capabilities exist? This paper provides a comprehensive description of when and why multidimensional simulation is needed.
    Keywords: Spacecraft Propulsion and Power
    Type: NASA/TM-2005-213975 , AIAA Paper 2005-5557 , E-15294 , Third International Energy Conversion Engineering Conference (IECEC-2005); Aug 15, 2005 - Aug 18, 2005; San Francisco, CA; United States
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    NASA TECHNICAL REPORTS
  • 5
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    Fast Whole-Engine Stirling Analysis (2005)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: An experimentally validated approach is described for fast axisymmetric Stirling engine simulations. These simulations include the entire displacer interior and demonstrate it is possible to model a complete engine cycle in less than an hour. The focus of this effort was to demonstrate it is possible to produce useful Stirling engine performance results in a time-frame short enough to impact design decisions. The combination of utilizing the latest 64-bit Opteron computer processors, fiber-optical Myrinet communications, dynamic meshing, and across zone partitioning has enabled solution times at least 240 times faster than previous attempts at simulating the axisymmetric Stirling engine. A comparison of the multidimensional results, calibrated one-dimensional results, and known experimental results is shown. This preliminary comparison demonstrates that axisymmetric simulations can be very accurate, but more work remains to improve the simulations through such means as modifying the thermal equilibrium regenerator models, adding fluid-structure interactions, including radiation effects, and incorporating mechanodynamics.
    Keywords: Spacecraft Propulsion and Power
    Type: NASA/TM-2005-213960 , AIAA Paper 2005-5558 , E-15276 , Third International Energy Conversion Engineering Conference; Aug 15, 2005 - Aug 18, 2005; San Francisco, CA; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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