ISSN:
1434-193X
Keywords:
Nucleophilic addition
;
Solvent effect
;
Reversal of diastereoselectivity
;
Temperature effect
;
Imines
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
-Commonly observed, but rarely explored, is the possibility of modifying the diastereomeric excess (de%) by means of temperature. A complete reversal in the diastereofacial selectivity could be obtained whenever the diastereoisomers concerned are differentially favored by enthalpy and entropy. The enthalpic or entropic dominance of a diastereoisomer depends greatly on the reaction solvent used.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
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