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  • 1
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    Loss of sex discrimination and male-male aggression in mice deficient for TRP2 (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-02-02
    Description: The mouse vomeronasal organ (VNO) is thought to mediate social behaviors and neuroendocrine changes elicited by pheromonal cues. The molecular mechanisms underlying the sensory response to pheromones and the behavioral repertoire induced through the VNO are not fully characterized. Using the tools of mouse genetics and multielectrode recording, we demonstrate that the sensory activation of VNO neurons requires TRP2, a putative ion channel of the transient receptor potential family that is expressed exclusively in these neurons. Moreover, we show that male mice deficient in TRP2 expression fail to display male-male aggression, and they initiate sexual and courtship behaviors toward both males and females. Our study suggests that, in the mouse, sensory activation of the VNO is essential for sex discrimination of conspecifics and thus ensures gender-specific behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stowers, Lisa -- Holy, Timothy E -- Meister, Markus -- Dulac, Catherine -- Koentges, Georgy -- DC03903/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 22;295(5559):1493-500. Epub 2002 Jan 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11823606" target="_blank"〉PubMed〈/a〉
    Keywords: *Aggression ; Animals ; Chemoreceptor Cells/*physiology ; Crosses, Genetic ; Cues ; Electrophysiology ; Electroporation ; Female ; Gene Targeting ; Male ; Maternal Behavior ; Membrane Proteins/*genetics/*physiology ; Mice ; Mice, Inbred C57BL ; Mutation ; Neurons, Afferent/*physiology ; Odors ; Olfactory Bulb/physiology ; Olfactory Mucosa/physiology ; Pheromones/*physiology/urine ; Sex Characteristics ; *Sexual Behavior, Animal ; Signal Transduction ; TRPC Cation Channels ; Video Recording ; Vomeronasal Organ/*innervation/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Responses of vomeronasal neurons to natural stimuli (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-09-01
    Description: The vomeronasal organ (VNO) of mammals plays an essential role in the detection of pheromones. We obtained simultaneous recordings of action potentials from large subsets of VNO neurons. These cells responded to components of urine by increasing their firing rate. This chemosensory activation required phospholipase C function. Unlike most other sensory neurons, VNO neurons did not adapt under prolonged stimulus exposure. The full time course of the VNO spiking response is captured by a simple quantitative model of ligand binding. Many individual VNO neurons were strongly selective for either male or female mouse urine, with the effective concentrations differing as much as a thousandfold. These results establish a framework for understanding sensory coding in the vomeronasal system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holy, T E -- Dulac, C -- Meister, M -- New York, N.Y. -- Science. 2000 Sep 1;289(5484):1569-72.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. timholy@mcb.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10968796" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Chemoreceptor Cells/metabolism ; Female ; Kinetics ; Ligands ; Male ; Mice ; Mice, Inbred DBA ; Models, Biological ; Neurons, Afferent/*physiology ; Pheromones/physiology/*urine ; Potassium/pharmacology ; Signal Transduction ; Type C Phospholipases/antagonists & inhibitors/metabolism ; Urine ; Vomeronasal Organ/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Concerted signaling by retinal ganglion cells (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-17
    Description: To analyze the rules that govern communication between eye and brain, visual responses were recorded from an intact salamander retina. Parallel observation of many retinal ganglion cells with a microelectrode array showed that nearby neurons often fired synchronously, with spike delays of less than 10 milliseconds. The frequency of such synchronous spikes exceeded the correlation expected from a shared visual stimulus up to 20-fold. Synchronous firing persisted under a variety of visual stimuli and accounted for the majority of action potentials recorded. Analysis of receptive fields showed that concerted spikes encoded information not carried by individual cells; they may represent symbols in a multineuronal code for vision.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meister, M -- Lagnado, L -- Baylor, D A -- EY01543/EY/NEI NIH HHS/ -- EY05750/EY/NEI NIH HHS/ -- EY10020/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1207-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502047" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; In Vitro Techniques ; Microelectrodes ; Photic Stimulation ; Retinal Ganglion Cells/*physiology ; Signal Transduction ; Urodela ; Vision, Ocular/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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