ISSN:
1432-1432
Keywords:
Phyletic trees from x-ray crystal structures
;
Sequences
;
Globins
;
Cytochromes
;
Immunoglobulins
;
Serine proteinases
;
Eye-lens gamma crystallins
;
Dinucleotide-binding proteins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary A distance measure that reflects the dissimilarity among structures has been developed on the basis of the three-dimensional structures of similar proteins, this being totally independent of sequence in the sense that only the relative spatial positions of mainchain alpha-carbon atoms need be known. This procedure leads to phyletic relationships that are in general correlated with the sequence phylogenies based on residue type. Such relationships among known protein three-dimensional structures are also a useful aid to their classification and selection in knowledge-based modeling using homologous structures. We have applied this approach to six homologous sets of proteins: immunoglobulin fragments, globins, cytochromesc, serine proteinases, eye-lens gamma crystallins, and dinucleotide-binding domains.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02102452
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