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  • Dihydrofolate  (1)
  • SPACECRAFT DESIGN, TESTING AND PERFORMANCE  (1)
  • 1990-1994  (2)
  • 1
    ISSN: 1617-4623
    Keywords: Thy−phenotype ; Suppression ; Folate levels ; Dihydrofolate ; Translational accuracy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Thymine-requiring strains of Escherichia coli suppress nonsense and frameshift mutants of T4 phage. We proposed that these mutants make errors during translation because of an imbalance in folate metabolism. A thymine-requiring strain grown under suppressing conditions has elevated levels of reduced folates. We tested the effect of either mutational blocks or the inhibition of various steps in folate biosynthesis on suppression. Conditions which prevent the accumulation of 5-methyl tetrahydrofolate inhibit suppression, suggesting that elevated levels of this folate are required for suppression. Furthermore, conditions that result in an accumulation in dihydrofolate inhibit suppression.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2019-07-13
    Description: A technique for calculating the effects of on-orbit loads on the structural dynamics of the International Space Station is developed on the basis of MSC/NASTRAN superelement solution sequences. The complexity of the Space Station program with its multiple configurations, international partners, and contractors is stressed, and the impact of this complexity on the dynamic-load analysis process is indicated. The MSC/NASTRAN-based approach is outlined, and its application to two versions of the Permanent Manned Capability configuration is described in detail, including component mode synthesis, GFSC/FLAME coupled-loads analysis (with components from the system FEM model or from the Work Package), and ISI/MATRIX-X generation of closed-loop forcing functions. The results of these sample analyses are presented in extensive tables and graphs and briefly characterized.
    Keywords: SPACECRAFT DESIGN, TESTING AND PERFORMANCE
    Type: AIAA PAPER 90-0995 , AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics and Materials Conference; Apr 02, 1990 - Apr 04, 1990; Long Beach, CA; United States
    Format: text
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