ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • SPACE VEHICLES  (3)
  • Diflunisal  (2)
  • 2-tridecanone  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of probenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal (1995)
    Springer
    European journal of clinical pharmacology 47 (1995), S. 519-523 
    Details
    ISSN: 1432-1041
    Keywords: Diflunisal ; Probenecid ; steady state pharmacokinetics ; glucuronidation ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The effect of probenecid on the pharmacokinetics of diflunisal and its glucuronide and sulphate conjugates was studied in 8 healthy volunteers. Diflunisal 250 mg b. d. was administered p. o. for 15 days and its steady state pharmacokinetics was evaluated on Day 16 after the last dose (control phase). Probenecid 500 mg b. d. was co-administered throughout the entire study period in the treatment phase of the study. The steady state plasma concentration of diflunisal was significantly higher during the probenecid treatment phase as compared to the control phase (104.0 vs. 63.1 μg·ml−1). This was the result of a significant decrease in the plasma clearance of diflunisal from 5.8 (control) to 3.4 ml·min−1 (probenecid co-administration). The metabolite formation clearances of both glucuronides were significantly decreased by probenecid, -45 % and -54 % for the phenolic and acyl glucuronide, respectively. The metabolite formation clearance of the sulphate conjugate was not affected by probenecid co-administration. Steady state plasma concentrations of the sulphate and glucuronide conjugates of diflunisal were 2.5- to 3.1-fold higher during probenecid co-administration, due to a significant reduction in the renal clearance of the three diflunisal conjugates. Probenecid also reduced the plasma protein binding of diflunisal, but only to a minor extent; the unbound plasma fraction of diflunisal at steady state averaged between 5 and 30 % higher during probenecid co-administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193705
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Both phenolic and acyl glucuronidation pathways of diflunisal are impaired in liver cirrhosis (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 471-474 
    Details
    ISSN: 1432-1041
    Keywords: Diflunisal ; Cirrhosis ; glucuronidation sulfation ; protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of diflunisal, a salicylate derivative that undergoes phenolic and acyl glucuronidation as well as sulphate conjugation, has been studied after a single oral dose (250 mg) in patients with cirrhosis (n=5) and in healthy controls (n=5). The plasma clearance of total (bound + unbound) diflunisal was 10.2 ml · min−1 in the control subjects and it was not affected by cirrhosis (10.9 ml · min−1). The plasma protein binding of diflunisal was significantly reduced in cirrhosis; the percentage of unbound diflunisal in plasma was 0.089 in the controls and 0.147 in the patients with cirrhosis. Plasma clearance of unbound diflunisal was significantly impaired in cirrhosis: 11.51 · min−1 in control subjects vs 7.41 · min−1 in cirrhotics. In cirrhotic patients, the unbound partial clearances to the phenolic and acyl glucuronides were both significantly reduced, by approximately 38%. The unbound partial clearance to the sulphate conjugate was not significantly affected by cirrhosis. The results show that both the phenolic and acyl glucuronidation pathways of diflunisal are equally susceptible to the effects of liver cirrhosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314852
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Morphology of the prothoracic defensive gland ofSchizura concinna (J.E. Smith) (Lepidoptera:Notodontidae) and the nature of its secretion (1979)
    Springer
    Journal of chemical ecology 5 (1979), S. 165-177 
    Details
    ISSN: 1573-1561
    Keywords: Schizura concinna ; Lepidoptera ; Notodontidae ; prothoracic ; defensive gland ; allomone ; defensive secretion ; decyl acetate ; dodecyl acetate ; 2-tridecanone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The larval defensive gland ofSchizura concinna (J.E. Smith) is situated in the thorax and consists of two sacs joined by an interglandular neck. Its orifice opens into a transverse invagination of the integument at the cervical margin of the prosternite. The major component of the defensive secretion, formic acid, was identified as itsp-bromophenacyl ester. Ancillary components decyl acetate, dodecyl acetate, and 2-tridecanone from the anterior portion of the gland were identified by GLC and GS-MS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00988232
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    facet.materialart.
    Unknown
    Experiment module concepts study. Volume 2: Experiments and mission operations (1970)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: The baseline experiment program is concerned with future space experiments and cover the scientific disciplines of astronomy, space physics, space biology, biomedicine and biotechnology, earth applications, materials science, and advanced technology. The experiments within each discipline are grouped into functional program elements according to experiments that support a particular area of research or investigation and experiments that impose similar or related demand on space station support systems. The experiment requirements on module subsystems, experiment operating modes and time profiles, and the role of the astronaut are discussed. Launch and rendezvous with the space station, disposal, and on-orbit operations are delineated. The operational interfaces between module and other system elements are presented and include space station and logistic system interfaces. Preliminary launch and on-orbit environmental criteria and requirements are discussed, and experiment equipment weights by functional program elements are tabulated.
    Keywords: SPACE VEHICLES
    Type: NASA-CR-117655 , GDC-DAA70-004-VOL-2
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 5
    facet.materialart.
    Unknown
    Free-flying modules - Interface and operation (1970)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Free-flying modules interface and operation in conjunction with space station for orbital research into manned space program
    Keywords: SPACE VEHICLES
    Type: AIAA PAPER 70-1300 , AMERICAN INST. OF AERONAUTICS AND ASTRONAUTICS, ANNUAL MEETING AND TECHNICAL DISPLAY, 7TH; Oct 19, 1970 - Oct 22, 1970; HOUSTON, TX
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 6
    facet.materialart.
    Unknown
    Research and applications modules /RAM/ (1973)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: RAM, a family of payload carriers that operate in conjunction with the Space Shuttle, is shown to provide flexible and economical laboratories and facilities for the conduct of manned and man-tended scientific and applications investigations in near-earth orbit. Two primary mission modes of RAM are discussed in terms of capability provided, and major advantages and constraints. The Sortie mission mode uses the Shuttle orbiter as the space platform and RAM as the scientific equipment carrier to provide a flexible and economical means for conducting short-duration manned investigations. The man-tended observatory mode uses Shuttle for delivery, periodic on-orbit update and service, and retrieval of the observatory, with RAM providing the interface with the Shuttle for servicing and the space platform functions for operation.
    Keywords: SPACE VEHICLES
    Type: Symposium on Space Shuttle Payloads; Dec 27, 1972 - Dec 08, 1972; Washington, DC
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...