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  • 1
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    The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-11-03
    Description: A complementary DNA (cDNA) for ubiquitin carboxyl-terminal hydrolase isozyme L3 was cloned from human B cells. The cDNA encodes a protein of 230 amino acids with a molecular mass of 26.182 daltons. The human protein is very similar to the bovine homolog, with only three amino acids differing in over 100 residues compared. The amino acid sequence deduced from the cDNA was 54% identical to that of the neuron-specific protein PGP 9.5. Purification of bovine PGP 9.5 confirmed that it is also a ubiquitin carboxyl-terminal hydrolase. These results suggest that a family of such related proteins exists and that their expression is tissue-specific.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilkinson, K D -- Lee, K M -- Deshpande, S -- Duerksen-Hughes, P -- Boss, J M -- Pohl, J -- New York, N.Y. -- Science. 1989 Nov 3;246(4930):670-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2530630" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; B-Lymphocytes/enzymology ; Base Sequence ; Cattle ; DNA/genetics ; Humans ; Isoenzymes/genetics ; Molecular Sequence Data ; Neuropeptides/*genetics/isolation & purification ; Sequence Homology, Nucleic Acid ; Thiolester Hydrolases/*genetics/isolation & purification ; Ubiquitin Thiolesterase
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Optical image quality and the cone mosaic (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-31
    Description: Contrary to the orthodox view that optical image quality should "match" the photoreceptor grain, anatomical data from the eyes of various animals suggest that the image quality is significantly superior to the potential resolution of the cone mosaic in most retinal regions. A new theory is presented to explain the existence of this relation and to better appreciate eye design. It predicts that photoreceptors are potentially visible through the natural optics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyder, A W -- Bossomaier, T R -- Hughes, A -- New York, N.Y. -- Science. 1986 Jan 31;231(4737):499-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3941914" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Humans ; Models, Neurological ; Photoreceptor Cells/*anatomy & histology ; Rats ; Snakes ; Species Specificity ; *Vision, Ocular ; *Visual Perception
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-12-23
    Description: Hypocalcemic vitamin D-resistant rickets is a human genetic disease resulting from target organ resistance to the action of 1,25-dihydroxyvitamin D3. Two families with affected children homozygous for this autosomal recessive disorder were studied for abnormalities in the intracellular vitamin D receptor (VDR) and its gene. Although the receptor displays normal binding of 1,25-dihydroxyvitamin D3 hormone, VDR from affected family members has a decreased affinity for DNA. Genomic DNA isolated from these families was subjected to oligonucleotide-primed DNA amplification, and each of the nine exons encoding the receptor protein was sequenced for a genetic mutation. In each family, a different single nucleotide mutation was found in the DNA binding domain of the protein; one family near the tip of the first zinc finger (Gly----Asp) and one at the tip of the second zinc finger (Arg----Gly). The mutant residues were created in vitro by oligonucleotide directed point mutagenesis of wild-type VDR complementary DNA and this cDNA was transfected into COS-1 cells. The produced protein is biochemically indistinguishable from the receptor isolated from patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, M R -- Malloy, P J -- Kieback, D G -- Kesterson, R A -- Pike, J W -- Feldman, D -- O'Malley, B W -- New York, N.Y. -- Science. 1988 Dec 23;242(4886):1702-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2849209" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites ; Calcitriol/metabolism ; Cell Line ; Cell Line, Transformed ; Codon ; DNA/genetics/metabolism ; Exons ; Female ; Gene Amplification ; Homozygote ; Humans ; Hypocalcemia/*genetics ; Immunoblotting ; Male ; Molecular Sequence Data ; *Mutation ; Receptors, Calcitriol ; Receptors, Steroid/*genetics/metabolism ; Rickets/*genetics ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    The 10.7-cm microwave observations of AR 5395 and related terrestrial effects (1989)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: The 10.7 cm flux patrols in Canada recorded 4 Great Bursts (peaks greater than 500 sfu) during the disk passage of AR 5395 in March 1989. The Great Bursts of 16 and 17 March were simple events of great amplitude and with half-life durations of only several minutes. Earlier Great Bursts, originating on 6 March towards the NE limb and on 10 March closer to the central meridian, belong to an entirely different category of event. Each started with a very strong impulsive event lasting just minutes. After an initial recovery, however, the emission climbed back to level as greater or greater than the initial impulsive burst. The events of 6 and 10 March stayed above the Great Burst threshold for at least 100 minutes. The second component of long duration in these cases is associated with Type 4 continuum emission and thus very likely with CMEs. Major geomagnetic disturbances did not occur as a result of the massive complex event of 6 March or the two simple but strong events of 16 and 17 March. But some 55 hours after the peak in the long-enduring burst of 10 March, a storm began which qualifies as the fourth strongest geomagnetic storm in Canada since 1932. The vertical component of the earth's field measured during the storm by a fluxgate magnetometer at a station in Manitoba is presented. Within a minute of the sudden commencement of this storm, a series of breakdowns began in the transmission system of Hydro-Quebec which resulted in a total loss of power, on a bitterly cold winter's day, for at least 10 hours. The loss of power provoked an enormous outcry from the public resulting in the power utilities being more receptive to the need to monitor solar as well as geomagnetic activity.
    Keywords: SOLAR PHYSICS
    Type: NASA, Goddard Space Flight Center, Max '91 Workshop 2: Developments in Observations and Theory for Solar Cycle 22; p 242-245
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  • 5
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    Magnetic fields in the overshoot zone: The great escape (1987)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: In order that magnetic flux be confined within the solar interior for times comparable to the solar cycle period it has been suggested that the bulk of the solar toroidal field is stored in the convectively stable overshoot region situated beneath the convection zone proper. Such a magnetic field, though, is still buoyant and is therefore subject to Rayleigh-Taylor type instabilities. The model problem of an isolated region of magnetic field embedded in a convectively stable atmosphere is considered. The fully nonlinear evolution of the two dimensional interchange of modes is studied, thereby shedding some light on one of the processes responsible for the escape of flux from the solar interior.
    Keywords: SOLAR PHYSICS
    Type: NASA-Goddard Space Flight Center, Theoretical Problems in High Resolution Solar Physics, 2; p 101-104
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  • 6
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    The nonlinear breakup of a magnetic layer - Instability to interchange modes (1988)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Motivated by considerations of the solar toroidal magnetic field, the behavior of a layer of uniform magnetic field embedded in a convectively stable atmosphere is studied. Since the field can support extra mass, such a configuration is top-heavy and thus instabilities of the Rayleigh-Taylor type can occur. For both static and rotating basic states, the evolution of the interchange modes (no bending of the field lines) is followed by integrating numerically the nonlinear compressible MHD equations. The initial Rayleigh-Taylor instability of the magnetic field gives rise to strong shearing motions, thereby exciting secondary Kelvin-Helmholtz instabilities which wrap the gas into regions of intense vorticity. The subsequent motions are determined primarily by the strong interactions between vortices which are responsible for the rapid disruption of the magnetic layer.
    Keywords: SOLAR PHYSICS
    Type: Journal of Fluid Mechanics (ISSN 0022-1120); 196; 323-344
    Format: text
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  • 7
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    The nonlinear breakup of the sun's toroidal field (1989)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: There are good reasons for believing that the sun has a strong toroidal magnetic field in the stably stratified region of convective overshoot sandwiched between the radiative zone and convective zone proper. The magnetic field in this region is modeled by studying the behavior of a layer of uniform field embedded in a subadiabatic atmosphere. Since the field can support extra mass, such a configuration is top-heavy, and instabilities of the Rayleigh-Taylor type can occur. Numerical integration of the two-dimensional compressible MHD equations makes it possible to follow the evolution of this instability into the nonlinear regime. The initial buoyancy-driven instability of the magnetic field gives rise to strong shearing motions, thereby exciting secondary Kelvin-Helmholtz instabilities which wrap the gas into regions of intense vorticity. The somewhat surprising subsequent motions are determined primarily by the strong interactions between vortices.
    Keywords: SOLAR PHYSICS
    Type: European Physical Society Study Conference; Jun 16, 1988 - Jun 21, 1988; Noto; Italy
    Format: text
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