ISSN:
1434-1948
Keywords:
Biaryls
;
Lactones
;
Nucleophilic additions
;
Ruthenium
;
S ligands
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The substitution-labile thiophene complex [CpRu{(S,S)-CHIRAPHOS}(SC4H4)]BF4 (2) [(S,S)-CHIRAPHOS = (2S,3S)bis(diphenylphosphanyl)butane], prepared from [CpRu{(S,S)-CHIRAPHOS}Cl] (1), thiophene, and AgBF4, reacted with the biaryl-thionolactones 3a-f to give the corresponding S-coordinated complexes 4a-f in high yields. The structure of 4c, which crystallized as the pure (S,S,P) diastereoisomer, was determined by X-ray crystallography. Coordination of the ruthenium fragment caused an elongation of the C=S bond, a contraction of the C-O bond within the lactone ring and a flattening of that ring. Single hydride transfer with LiBEt3H converted 4a-f into the thiolactolate complexes 5a-f in good yields and diastereoselectivities. An X-ray structure determination of the major isomer of 5a revealed it to be the (S,S,S,P) diastereoisomer. Protonation with NH4PF6 converted 5a-f into the corresponding ring-opened thioaldehyde complexes 6a-f. Alkylation of 5a with methyl iodide resulted in Ru-S cleavage to give the oxothioacetal 7a and [CpRu{(S,S)-CHIRAPHOS}I] (8). Full reduction of 4a-f with LiAlH4 produced the thiolate complexes 9a-f in high yields and 6-74% de. Methylation at sulfur converted 9a-c into the corresponding thioether complexes 10a-c, which were cleaved to 8 and the free methyl thioethers 11a-c without isomerization of the biaryl axis.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
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