ISSN:
0947-3440
Keywords:
Host-guest chemistry
;
Calix[4]arenes
;
Resorcin[4]arenes
;
Dimerization
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Receptor molecules with a preorganized cavity were synthesized by combining two resorcin[4]arene and one calix[4]-arene building block. Based on predictions from a computational study which matches hosts and guests, several steroids, sugar derivatives, and alkaloids were selected for complexation studies. Experimentally the complexation of such guests by these receptor molecules was proven by 1H-NMR spectroscopy (association constants of 1.0-6.0 × 102 M-1 in CDCl3). One of these receptors with four hydroxyl groups forms a dimeric capsule (Kdimer = 11 M-1 in CDCl3). Evidence for this dimerization comes from 1H-NMR, FAB MS spectroscopy, and molecular mechanics and dynamics calculations.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199719970739
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