ISSN:
0749-1581
Keywords:
Cyclazocine
;
13CNMR
;
Relaxation times
;
Reorientational dynamics
;
Internal mobility
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The motional behaviour of the mixed agonist-antagonist opioid narcotic cyclazocine (2-cyclopropylmethyl-2′-hydroxy-5,9-dimethyl-6,7-benzomorphan) as a cationic species (CLZH +) was analysed by 13C NMR spin-lattice relaxation times (T1). Both AM1 and MM2 theoretical calculations were performed to predict the preferred conformations and torsional energetics of CLZH+ in the vapour phase. The analysis of the experimental T1 data (in aqueous solution) was performed by using an analytical model to describe the overall and internal motions of the molecule. The best fit of the relaxation times allowed the detection, in the liquid phase, of effective solute-solvent interactions and the fully anisotropic diffusive process of the molecule. The motional parameters obtained indicated an increased retational anisotropy of CLZH+ on passing from the gas phase to the solution state. Different activation energies arising from separate solvation effects were found for the motion of the 10-Me and 11-Me groups. The fitted energies and transition energies matrix relative to the internal motion of the N-cyclopropylmethyl group indicated that the preferred conformational states are not isolated and that the overall and internal motions are of the same order of magnitude.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260310906
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