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  • 1
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    Specific heat of matter formed in relativistic nuclear collisions (2016)
    American Physical Society (APS)
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    Publication Date: 2016-10-04
    Description: Author(s): Sumit Basu, Sandeep Chatterjee, Rupa Chatterjee, Tapan K. Nayak, and Basanta K. Nandi We report the excitation energy dependence of specific heat ( c v ) of hadronic matter at freeze-out in Au+Au and Cu+Cu collisions at the BNL Relativistic Heavy Ion Collider energies by analyzing the published data on event-by-event mean transverse momentum ( 〈 p T 〉 ) distributions. The 〈 p T 〉 distributions … [Phys. Rev. C 94, 044901] Published Mon Oct 03, 2016
    Keywords: Relativistic Nuclear Collisions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Triangular flow of thermal photons from an event-by-event hydrodynamic model for 2.76A TeV Pb + Pb collisions at the CERN Large Hadron Collider (2016)
    American Physical Society (APS)
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    Publication Date: 2016-07-07
    Description: Author(s): Rupa Chatterjee, Dinesh K. Srivastava, and Thorsten Renk We calculate the triangular flow parameter v 3 of thermal photons from an event-by-event ideal hydrodynamic model for 0–40% central collisions of Pb nuclei at s N N = 2.76 TeV at the CERN Large Hadron Collider. v 3 determined with respect to the participant plane (PP) is found to be nonzero and positive, … [Phys. Rev. C 94, 014903] Published Wed Jul 06, 2016
    Keywords: Relativistic Nuclear Collisions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 3
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    Initial conditions from the shadowed Glauber model for Pb + Pb collisions at sqrt[s_{NN} ] =2.76 TeV (2016)
    American Physical Society (APS)
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    Publication Date: 2016-05-10
    Description: Author(s): Snigdha Ghosh, Sushant K. Singh, Sandeep Chatterjee, Jane Alam, and Sourav Sarkar We study the initial conditions for Pb + Pb collisions at s N N = 2.76  TeV using the two-component Monte-Carlo Glauber model with shadowing of the nucleons in the interior by the leading ones. The model parameters are fixed by comparing them to the multiplicity data of p + Pb and Pb + Pb collisions at s N N = 5.0… [Phys. Rev. C 93, 054904] Published Mon May 09, 2016
    Keywords: Relativistic Nuclear Collisions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Separation of flow from the chiral magnetic effect in U + U collisions using spectator asymmetry (2015)
    American Physical Society (APS)
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    Publication Date: 2015-07-08
    Description: Author(s): Sandeep Chatterjee and Prithwish Tribedy We demonstrate that the prolate shape of the uranium nucleus generates anticorrelation between spectator asymmetry and initial-state ellipticity of the collision zone, providing a way to constrain the initial event shape in U + U collisions. As an application, we show that this can be used to separa… [Phys. Rev. C 92, 011902(R)] Published Tue Jul 07, 2015
    Keywords: Relativistic Nuclear Collisions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 5
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    Collision centrality and τ_{0} dependence of the emission of thermal photons from a fluctuating initial state in an ideal hydrodynamic calculation (2012)
    American Physical Society (APS)
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    Publication Date: 2012-06-16
    Description: Author(s): Rupa Chatterjee, Hannu Holopainen, Thorsten Renk, and Kari J. Eskola Fluctuations in the initial QCD matter density distribution are found to enhance the production of thermal photons significantly in the range 2⩽ p T ⩽4 GeV/ c compared to a smooth initial state averaged profile in ideal hydrodynamic calculation for 200 A  GeV Au+Au collisions at the Relativistic Heavy Ion... [Phys. Rev. C 85, 064910] Published Fri Jun 15, 2012
    Keywords: Relativistic Nuclear Collisions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 6
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    Enhancement of thermal photon production in event-by-event hydrodynamics (2011)
    American Physical Society (APS)
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    Publication Date: 2011-05-24
    Description: Author(s): Rupa Chatterjee, Hannu Holopainen, Thorsten Renk, and Kari J. Eskola Thermal photon emission is widely believed to reflect properties of the earliest, hottest evolution stage of the medium created in ultrarelativistic heavy-ion collisions. Previous computations of photon emission have been carried out using a hydrodynamical medium description with smooth, averaged in... [Phys. Rev. C 83, 054908] Published Mon May 23, 2011
    Keywords: Relativistic Nuclear Collisions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 7
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    Production of light nuclei in heavy-ion collisions within a multiple-freezeout scenario (2014)
    American Physical Society (APS)
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    Publication Date: 2014-09-17
    Description: Author(s): Sandeep Chatterjee and Bedangadas Mohanty We discuss the production of light nuclei in heavy ion collisions within a multiple freezeout scenario. Thermal parameters extracted from the fits to the observed hadron yields are used to predict the multiplicities of light nuclei. Ratios of strange to nonstrange nuclei are found to be most sensiti... [Phys. Rev. C 90, 034908] Published Tue Sep 16, 2014
    Keywords: Relativistic Nuclear Collisions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 8
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    Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence (1999)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1999-02-05
    Description: Mycobacterium ulcerans is the causative agent of Buruli ulcer, a severe human skin disease that occurs primarily in Africa and Australia. Infection with M. ulcerans results in persistent severe necrosis without an acute inflammatory response. The presence of histopathological changes distant from the site of infection suggested that pathogenesis might be toxin mediated. A polyketide-derived macrolide designated mycolactone was isolated that causes cytopathicity and cell cycle arrest in cultured L929 murine fibroblasts. Intradermal inoculation of purified toxin into guinea pigs produced a lesion similar to that of Buruli ulcer in humans. This toxin may represent one of a family of virulence factors associated with pathology in mycobacterial diseases such as leprosy and tuberculosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉George, K M -- Chatterjee, D -- Gunawardana, G -- Welty, D -- Hayman, J -- Lee, R -- Small, P L -- New York, N.Y. -- Science. 1999 Feb 5;283(5403):854-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9933171" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Toxins/chemistry/*isolation & purification/*toxicity ; Cell Cycle/drug effects ; Chromatography, High Pressure Liquid ; Chromatography, Thin Layer ; Female ; Guinea Pigs ; L Cells (Cell Line) ; Macrolides ; Mass Spectrometry ; Mice ; Mycobacterium Infections, Nontuberculous/microbiology/pathology ; Mycobacterium ulcerans/chemistry/*pathogenicity ; Necrosis ; Skin/microbiology/pathology ; Skin Diseases, Bacterial/microbiology/pathology ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-05-02
    Description: Numerous post-translational modifications of histones have been described in organisms ranging from yeast to humans. Growing evidence for dynamic regulation of these modifications, position- and modification-specific protein interactions, and biochemical crosstalk between modifications has strengthened the 'histone code' hypothesis, in which histone modifications are integral to choreographing the expression of the genome. One such modification, ubiquitylation of histone H2B (uH2B) on lysine 120 (K120) in humans, and lysine 123 in yeast, has been correlated with enhanced methylation of lysine 79 (K79) of histone H3 (refs 5-8), by K79-specific methyltransferase Dot1 (KMT4). However, the specific function of uH2B in this crosstalk pathway is not understood. Here we demonstrate, using chemically ubiquitylated H2B, a direct stimulation of hDot1L-mediated intranucleosomal methylation of H3 K79. Two traceless orthogonal expressed protein ligation (EPL) reactions were used to ubiquitylate H2B site-specifically. This strategy, using a photolytic ligation auxiliary and a desulphurization reaction, should be generally applicable to the chemical ubiquitylation of other proteins. Reconstitution of our uH2B into chemically defined nucleosomes, followed by biochemical analysis, revealed that uH2B directly activates methylation of H3 K79 by hDot1L. This effect is mediated through the catalytic domain of hDot1L, most likely through allosteric mechanisms. Furthermore, asymmetric incorporation of uH2B into dinucleosomes showed that the enhancement of methylation was limited to nucleosomes bearing uH2B. This work demonstrates a direct biochemical crosstalk between two modifications on separate histone proteins within a nucleosome.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774535/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774535/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGinty, Robert K -- Kim, Jaehoon -- Chatterjee, Champak -- Roeder, Robert G -- Muir, Tom W -- GM07739/GM/NIGMS NIH HHS/ -- R01 GM086868/GM/NIGMS NIH HHS/ -- England -- Nature. 2008 Jun 5;453(7196):812-6. doi: 10.1038/nature06906. Epub 2008 Apr 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, New York 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18449190" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Animals ; Catalytic Domain ; Histones/chemical synthesis/*metabolism ; Humans ; Lysine/metabolism ; Methylation ; Methyltransferases/genetics/*metabolism ; Nucleosomes/chemistry/*metabolism ; Ubiquitin/*metabolism ; Xenopus
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Active turnover modulates mature microRNA activity in Caenorhabditis elegans (2009)
    Nature Publishing Group (NPG)
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    Publication Date: 2009-09-08
    Description: MicroRNAs (miRNAs) constitute a large class of regulatory RNAs that repress target messenger RNAs to control various biological processes. Accordingly, miRNA biogenesis is highly regulated, controlled at both transcriptional and post-transcriptional levels, and overexpression and underexpression of miRNAs are linked to various human diseases, particularly cancers. As RNA concentrations are generally a function of biogenesis and turnover, active miRNA degradation might also modulate miRNA accumulation, and the plant 3'--〉5' exonuclease SDN1 has been implicated in miRNA turnover. Here we report that degradation of mature miRNAs in the nematode Caenorhabditis elegans, mediated by the 5'--〉3' exoribonuclease XRN-2, affects functional miRNA homeostasis in vivo. We recapitulate XRN-2-dependent miRNA turnover in larval lysates, where processing of precursor-miRNA (pre-miRNA) by Dicer, unannealing of the miRNA duplex and loading of the mature miRNA into the Argonaute protein of the miRNA-induced silencing complex (miRISC) are coupled processes that precede degradation of the mature miRNA. Although Argonaute:miRNA complexes are highly resistant to salt, larval lysate promotes efficient release of the miRNA, exposing it to degradation by XRN-2. Release and degradation can both be blocked by the addition of miRNA target RNA. Our results therefore suggest the presence of an additional layer of regulation of animal miRNA activity that might be important for rapid changes of miRNA expression profiles during developmental transitions and for the maintenance of steady-state concentrations of miRNAs. This pathway might represent a potential target for therapeutic intervention on miRNA expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chatterjee, Saibal -- Grosshans, Helge -- England -- Nature. 2009 Sep 24;461(7263):546-9. doi: 10.1038/nature08349. Epub 2009 Sep 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friedrich Miescher Institute for Biomedical Research, PO Box 2543, CH-4002 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19734881" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/enzymology/*genetics/growth & development ; Caenorhabditis elegans Proteins/genetics/*metabolism ; Exoribonucleases/deficiency/genetics/*metabolism ; Gene Expression Regulation, Developmental ; Larva/genetics ; MicroRNAs/*genetics/*metabolism ; *RNA Stability ; RNA, Helminth/genetics/metabolism ; RNA-Induced Silencing Complex/chemistry/metabolism ; Ribonuclease III/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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