Publication Date:
1993-04-30
Description:
Sensorineural hearing loss resulting from the loss of auditory hair cells is thought to be irreversible in mammals. This study provides evidence that retinoic acid can stimulate the regeneration in vitro of mammalian auditory hair cells in ototoxic-poisoned organ of Corti explants in the rat. In contrast, treatment with retinoic acid does not stimulate the formation of extra hair cells in control cultures of Corti's organ. Retinoic acid-stimulated hair cell regeneration can be blocked by cytosine arabinoside, which suggests that a period of mitosis is required for the regeneration of auditory hair cells in this system. These results provide hope for a recovery of hearing function in mammals after auditory hair cell damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lefebvre, P P -- Malgrange, B -- Staecker, H -- Moonen, G -- Van de Water, T R -- DC00088/DC/NIDCD NIH HHS/ -- NS07098/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1993 Apr 30;260(5108):692-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Physiology and Pathophysiology, University of Liege, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8480180" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cytarabine/pharmacology
;
Hair Cells, Auditory/*drug effects/physiology/ultrastructure
;
Microscopy, Electron
;
Neomycin/toxicity
;
Organ Culture Techniques
;
Organ of Corti/*drug effects/physiology/ultrastructure
;
Rats
;
Regeneration/*drug effects
;
Tretinoin/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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