ISSN:
1420-9071
Keywords:
Radioprotection
;
cell cultures
;
isoproterenol
;
β-adrenoreceptor
;
cellular cAMP concentration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary In mixed culture of Chinese hamster fibroblatst, clone 431, and transformed murine L fibroblasts, clone B-82, isoproterenol was found to protect only 431 cells against ionizing radiation. It was shown that 431 cells, in contrast to B-82 cells, possessβ-adrenoreceptors, and the radioprotective effect of isoproterenol can be realized only if this agent interacts withβ-adrenoreceptors coupled with the cAMP system. Since malignization often causes the disappearance ofβ-adrenergic and other hormone receptors, the combined culturing and irradiation of the cells studied can be regarded as a model of the growth of malignant cells (B-82) among normal tissue cells (431 cells) under conditions of radiation therapy. A possibility of selective protection against radiation damage of normal tissue cells, with retention of the former radiosensitivity of tumor cells, is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01950019
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