Publication Date:
1989-06-23
Description:
In prokaryotes and eukaryotes mobile genetic elements frequently disrupt the highly conservative structures of chromosomes, which are responsible for storage of genetic information. The factors determining the site for integration of such elements are still unknown. Transfer RNA (tRNA) genes are associated in a highly significant manner with different putative mobile genetic elements in the cellular slime mold Dictyostelium discoideum. These results suggest that tRNA genes in D. discoideum, and probably tRNA genes generally in lower eukaryotes, may function as genomic landmarks for the integration of different transposable elements in a strictly position-specific manner.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marschalek, R -- Brechner, T -- Amon-Bohm, E -- Dingermann, T -- New York, N.Y. -- Science. 1989 Jun 23;244(4911):1493-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Biochemie der Medizinischen Fakultat, Universitat Erlangen-Nurnberg, Federal Republic of Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2567533" target="_blank"〉PubMed〈/a〉
Keywords:
Base Sequence
;
Chromosome Mapping
;
Dictyostelium/*genetics
;
Molecular Sequence Data
;
Nucleic Acid Hybridization
;
Oligonucleotide Probes
;
Polymorphism, Restriction Fragment Length
;
RNA, Transfer/*genetics
;
RNA, Transfer, Glu/genetics
;
RNA, Transfer, Lys/genetics
;
RNA, Transfer, Val/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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