Publication Date:
2012-03-17
Description:
Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported widespread differences between the RNA and DNA sequences of the same human cells, including all 12 possible mismatch types. Before accepting such a fundamental claim, a deeper analysis of the sequencing data is required to discern true differences between RNA and DNA from potential artifacts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Wei -- Piskol, Robert -- Tan, Meng How -- Li, Jin Billy -- New York, N.Y. -- Science. 2012 Mar 16;335(6074):1302; author reply 1302. doi: 10.1126/science.1210624.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22422964" target="_blank"〉PubMed〈/a〉
Keywords:
DNA/*genetics
;
*Genetic Variation
;
*Genome, Human
;
Humans
;
RNA, Messenger/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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