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  • 1
    Publication Date: 2024-04-05
    Description: Spatial-hearing ability has been found to vary widely across listeners. A survey of the existing auditory-space perception literature suggests that three main types of factors may account for this variability: - physical factors, e.g., acoustical characteristics related to sound-localization cues, - perceptual factors, e.g., sensory/cognitive processing, perceptual learning, multisensory interactions, - and methodological factors, e.g., differences in stimulus presentation methods across studies. However, the extent to which these–and perhaps other, still unidentified—factors actually contribute to the observed variability in spatial hearing across individuals with normal hearing or within special populations (e.g., hearing-impaired listeners) remains largely unknown. Likewise, the role of perceptual learning and multisensory interactions in the emergence of a multimodal but unified representation of “auditory space,” is still an active topic of research. A better characterization and understanding of the determinants of inter-individual variability in spatial hearing, and of its relationship with perceptual learning and multisensory interactions, would have numerous benefits. In particular, it would enhance the design of rehabilitative devices and of human-machine interfaces involving auditory, or multimodal space perception, such as virtual auditory/multimodal displays in aeronautics, or navigational aids for the visually impaired. For this Research Topic, we have considered manuscripts that: - present new methods, or review existing methods, for the study of inter-individual differences; - present new data (or review existing) data, concerning acoustical features relevant for explaining inter-individual differences in sound-localization performance; - present new (or review existing) psychophysical or neurophysiological findings concerning spatial hearing and/or auditory perceptual learning, and/or multisensory interactions in humans (normal or impaired, young or older listeners) or other species; - discuss the influence of inter-individual differences on the design and use of assistive listening devices (rehabilitation) or human-machine interfaces involving spatial hearing or multimodal perception of space (ergonomy).
    Keywords: RC321-571 ; BF1-990 ; Q1-390 ; Learning ; HRTF (head related transfer function) ; Sound Localization ; spatial hearing ; adaptation ; training ; binaural cues ; spectral cues ; mulltisensory interaction ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 2
    Publication Date: 2024-04-05
    Description: Perseverative cognition is defined as the repetitive or sustained activation of cognitive representations of past stressful events or feared events in the future and even at non-clinical levels it causes a “fight-or-flight” action tendency, followed by a cascade of biological events, starting in the brain and ending as peripheral stress responses. In the past decade, such persistent physiological activation has proven to impact individuals’ health, potentially leading to somatic disease. As such, perseverative cognition has recently been proposed as the missing piece in the relationships between stress, psychopathology, and risk for health. Perseverative cognition is indeed a hallmark of conditions such as anxiety and mood disorders that are at increased -though still unexplained- cardiovascular risk. Although the pivotal role of ruminative and worrisome thoughts in determining the onset and maintenance of psychopathological disorders has been acknowledged for a long time, its effects on the body via reciprocal influences between mental processes and the body's physiology have been neglected. Moreover, perseverative cognition is definitely not restricted to psychopathology, it is extremely common and likely even omnipresent, pervading daily life. The objective of the Research Topic is to provide an interdisciplinary examination of cutting-edge neuroscientific research on brain-body signatures of perseverative cognition in both healthy and psychopathological individuals. Despite the evident role of the brain in repetitive thinking and the assumption that our mind is embodied, bran-body pathways from perseverative cognition to health risk have remained largely unexplored.
    Keywords: RC321-571 ; Q1-390 ; functional connectivity ; brain-body interaction ; perseverative cognition ; heart rate variability ; generalized anxiety disorder ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 3
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: During the last decades, investigations on the olivo-cerebellar system have attained a high level of sophistication, which led to redefinitions of several structural and functional properties of neurons, synapses, connections and circuits. Research has expanded and deepened in so many directions and so many theories and models have been proposed that an ensemble review of the matter is now needed. Yet, hot topics remain open and scientific discussion is very lively at several fronts. One major question, here as well as in other major brain circuits, is how single neurons and synaptic properties emerge at the network level and contribute to behavioural regulation via neuronal plasticity. Other major aspects that this Research Topic covers and discusses include the development and circuit organization of the olivo-cerebellar network, the established and recent theories of learning and motor control, and the emerging role of the cerebellum in cognitive processing. By touching on such varied and encompassing subjects, this Frontiers Special Topic aims to highlight the state of the art and stimulate future research. We hope that this unique collection of high-quality articles from experts in the field will provide scientists with a powerful basis of knowledge and inspiration to enucleate the major issues deserving further attention.
    Keywords: RC321-571 ; Q1-390 ; Climbing fibres ; network synchrony ; compartmental organization ; Sensorimotor control ; Cerebellar Nuclei ; plasticity ; Purkinje cell ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 4
    Publication Date: 2024-04-05
    Description: Vision is the process of extracting behaviorally-relevant information from patterns of light that fall on retina as the eyes sample the outside world. Traditionally, nonhuman primates (macaque monkeys, in particular) have been viewed by many as the animal model-of-choice for investigating the neuronal substrates of visual processing, not only because their visual systems closely mirror our own, but also because it is often assumed that “simpler” brains lack advanced visual processing machinery. However, this narrow view of visual neuroscience ignores the fact that vision is widely distributed throughout the animal kingdom, enabling a wide repertoire of complex behaviors in species from insects to birds, fish, and mammals. Recent years have seen a resurgence of interest in alternative animal models for vision research, especially rodents. This resurgence is partly due to the availability of increasingly powerful experimental approaches (e.g., optogenetics and two-photon imaging) that are challenging to apply to their full potential in primates. Meanwhile, even more phylogenetically distant species such as birds, fish, and insects have long been workhorse animal models for gaining insight into the core computations underlying visual processing. In many cases, these animal models are valuable precisely because their visual systems are simpler than the primate visual system. Simpler systems are often easier to understand, and studying a diversity of neuronal systems that achieve similar functions can focus attention on those computational principles that are universal and essential. This Research Topic provides a survey of the state of the art in the use of animal models of visual functions that are alternative to macaques. It includes original research, methods articles, reviews, and opinions that exploit a variety of animal models (including rodents, birds, fishes and insects, as well as small New World monkey, the marmoset) to investigate visual function. The experimental approaches covered by these studies range from psychophysics and electrophysiology to histology and genetics, testifying to the richness and depth of visual neuroscience in non-macaque species.
    Keywords: RC321-571 ; Q1-390 ; object recognition ; Illusions ; Vision ; rodent ; fish ; Amblyopia ; insect ; Perception ; Visual Cortex ; marmoset ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 5
    Publication Date: 2024-04-05
    Description: For several decades, theory and research has drawn links between dopaminergic neurotransmission and various aspects of personality and individual differences, as well as major personality processes. Recent increases in the availability and affordability of neuroscience methods have permitted thorough investigation of such links as part of the thriving field of personality neuroscience. However, the picture emerging from this body of research is somewhat puzzling; Rather than being linked to only a few converging dimensions of individual differences in psychological functioning, dopamine seems to be associated with a wide range of rather disparate traits and psychopathological conditions including (among various others) impulsivity, extraversion, anxiety, reward sensitivity, approach behaviour, achievement motivation, working memory performance, cognitive flexibility, depression, anhedonia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Empirical research in this area typically focuses on only one piece of this puzzle based on a specific strand of theory and a narrow section of relevant prior findings. The present research topic will, for the first time, attempt to provide a fairly complete picture of the whole puzzle including all its disparate parts. Contributors will therefore be explicitly encouraged to go beyond their own specific dopamine-personality hypotheses and place their work in a broader context, thereby helping to forge links between largely non-overlapping research traditions.
    Keywords: RC321-571 ; Q1-390 ; Dopamine ; Extraversion ; Personality ; schizotypy ; Reward ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 6
    Publication Date: 2024-04-05
    Description: Stochastic fluctuations are intrinsic to and unavoidable at every stage of neural dynamics. For example, ion channels undergo random conformational changes, neurotransmitter release at synapses is discrete and probabilistic, and neural networks are embedded in spontaneous background activity. The mathematical and computational tool sets contributing to our understanding of stochastic neural dynamics have expanded rapidly in recent years. New theories have emerged detailing the dynamics and computational power of the balanced state in recurrent networks. At the cellular level, novel stochastic extensions to the classical Hodgkin-Huxley model have enlarged our understanding of neuronal dynamics and action potential initiation. Analytical methods have been developed that allow for the calculation of the firing statistics of simplified phenomenological integrate-and-fire models, taking into account adaptation currents or temporal correlations of the noise. This Research Topic is focused on identified physiological/internal noise sources and mechanisms. By "internal", we mean variability that is generated by intrinsic biophysical processes. This includes noise at a range of scales, from ion channels to synapses to neurons to networks. The contributions in this Research Topic introduce innovative mathematical analysis and/or computational methods that relate to empirical measures of neural activity and illuminate the functional role of intrinsic noise in the brain.
    Keywords: RC321-571 ; Q1-390 ; Balanced network ; Hodgkin-Huxley model ; neuronal variability ; Channel noise ; neural networks ; heterogeneity ; stochastic dynamics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 7
    Publication Date: 2024-04-05
    Description: The Reeler mutation was so named because of the alterations in gait that characterize homozygous mice. Several decades after the description of the Reeler phenotype, the mutated protein was discovered and named Reelin (Reln). Reln controls a number of fundamental steps in embryonic and postnatal brain development. A prominent embryonic function is the control of radial neuronal migration. As a consequence, homozygous Reeler mutants show disrupted cell layering in cortical brain structures. Reln also promotes postnatal neuronal maturation. Heterozygous mutants exhibit defects in dendrite extension and synapse formation, correlating with behavioral and cognitive deficits that are detectable at adult ages. The Reln-encoding gene is highly conserved between mice and humans. In humans, homozygous RELN mutations cause lissencephaly with cerebellar hypoplasia, a severe neuronal migration disorder that is reminiscent of the Reeler phenotype. In addition, RELN deficiency or dysfunction is also correlated with psychiatric and cognitive disorders, such as schizophrenia, bipolar disorder and autism, as well as some forms of epilepsy and Alzheimer's disease. Despite the wealth of anatomical studies of the Reeler mouse brain, and the molecular dissection of Reln signaling mechanisms, the consequences of Reln deficiency on the development and function of the human brain are not yet completely understood. This Research Topic include reviews that summarize our current knowledge of the molecular aspects of Reln function, original articles that advance our understanding of its expression and function in different brain regions, and reviews that critically assess the potential role of Reln in human psychiatric and cognitive disorders.
    Keywords: RC321-571 ; Q1-390 ; Neurons ; neuronal migration ; Schizophrenia ; Depression ; Neuronal Death ; Reeler ; Synapses ; autism ; intracellular pathways ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 8
    Publication Date: 2024-04-05
    Description: The cytoplasmic free Ca2+ concentration ([Ca2+]i) is a key determinant of neuronal information transfer and processing. It controls a plethora of fundamental processes, including transmitter release and the induction of synaptic plasticity. This enigmatic second messenger conveys its wide variety of actions by binding to a subgroup of Ca2+ binding proteins (CaBPs) known as “Ca2+ sensors”. Well known examples of Ca2+ sensors are Troponin-C in skeletal muscle, Synaptotagmin in presynaptic terminals, and Calmodulin (CaM) in all eukaryotic cells. Since the levels of [Ca2+]i directly influence the potency of Ca2+ sensors, the Ca2+ concentration is tightly controlled by several mechanisms including another type of Ca2+ binding proteins, the Ca2+ buffers. Prominent examples of Ca2+ buffers include Parvalbumin (PV), Calbindin-D28k (CB) and Calretinin (CR), although for the latter two Ca2+ sensor functions were recently also suggested. Ca2+ buffers are distinct from sensors by their purely buffering action, i.e. they influence the spatio-temporal extent of Ca2+ signals, without directly binding downstream target proteins. Details of their action depend on their binding kinetics, mobility, and concentration. Thus, neurons can control the range of action of Ca2+ by the type and concentration of CaBPs expressed. Since buffering strongly limits the range of action of free Ca2+, the structure of the Ca2+ signaling domain and the topographical relationships between the sites of Ca2+ influx and the location of the Ca2+ sensors are central determinants in neuronal information processing. For example, postsynaptic dendritic spines act to compartmentalize Ca2+ depending on their geometry and expression of CaBPs, thereby influencing dendritic integration. At presynaptic sites it has been shown that tight, so called nanodomain coupling between Ca2+ channels and the sensor for vesicular transmitter release increases speed and reliability of synaptic transmission. Vice versa, the influence of an individual CaBP on information processing depends on the topographical relationships within the signaling domain. If e.g. source and sensor are very close, only buffers with rapid binding kinetics can interfere with signaling. This Research Topic contains a collection of work dealing with the relationships between different [Ca2+]i controlling mechanisms in the structural context of synaptic sites and their functional implications for synaptic information processing as detailed in the Editorial.
    Keywords: RC321-571 ; Q1-390 ; localization ; dendritic integration ; calcium buffer ; storm ; Calcium ; transmitter release ; calcium sensor ; STED ; plasticity ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 9
    Publication Date: 2024-04-05
    Description: Ethanol is a very elusive drug, which has mechanisms of action that are diverse and relatively non-selective. Moreover, ethanol has been demonstrated to be a biologically active substance by itself, but also a pro-drug of the neuroactive metabolites, acetaldehyde and acetate. Acetaldehyde has traditionally been known as a toxic substance with several effects on multiple systems. However, in the last few decades evidence has accumulated to reveal the specific and, in some instances, distinct neural actions of acetaldehyde and acetate that are in part responsible for some of the observed psychoactive effects of ethanol. The present issue will address these challenges to provide an up-to-date synopsis of the behavioral and neurophysiological impact of the two direct metabolites of ethanol, acetaldehyde and acetate. In doing so, this issue will present human and rodent evidence on their behavioral and neurophysiological impact, either when administered alone as drugs, or when metabolically-derived from their parent compound. Emphasis will be placed to stress the importance of the different enzymatic systems that intervene to produce these metabolites, either peripherally and/or directly in the brain. Similarly, this Research Topic will be aimed at addressing some of the possible mechanisms of action of acetaldehyde and acetate in different brain areas and in different intracellular systems. Furthermore, the issue will lay out some of the suggested mechanisms of action of ethanol and of its metabolites by which they form adducts with other molecules and neurotransmitters such as dopamine and opioids (which lead to salsolinol and tetrahydropapaveroline, respectively), and their impact on the synthesis and actions of neuromodulators such as adenosine and the cannabinoid system.
    Keywords: RC321-571 ; Q1-390 ; acetate ; Drug abuse ; Salsolinol ; Dopamine ; Ethanol ; Catalase ; Addiction ; Opioids ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 10
    Publication Date: 2024-04-05
    Description: Recent advances in the neuroimaging field areas allow us to visualize the aggregate of neural connections at the macroscopic level within the brain, the so-called “connectome”. In order to promote the development of the neurophysiological investigation of connectome of brain oscillations, this eBook aims at bringing together contributions from researchers in basic and clinical neuroscience using EEG and MEG connectome analysis. The most important focal point will be to address the functional roles of connectome of brain oscillations in contributing to understandings of higher cognitive processes in normal subjects and pathophysiology of psychiatric diseases. This Research Topic presented novel methodologies and various applications of neurophysiological connectome analysis. As a result, these papers were cited more than 120 times in these four years in total and threw light and impact on new directions for investigating the connectome of human brain.
    Keywords: RC321-571 ; Q1-390 ; iCoh ; connectivity ; Default Mode Network ; EEG ; ICA ; Frontal Midline Theta ; connectome ; LORETA ; Alzheimer's disease ; MEG ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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