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  • 1
    Electronic Resource
    Electronic Resource
    The risks of handling cytotoxic drugs (1990)
    Springer
    Pharmacy world & science 12 (1990), S. 217-227 
    Details
    ISSN: 1573-739X
    Keywords: Antineoplastic agents ; Drug compounding ; Drug contamination ; Exposure, occupational ; Health-care personnel ; Mutagenicity tests ; Occupational health ; Protective devices
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Results of various biological and physical/chemical tests of the urines or blood of health-care personnel working with cytotoxic drugs are discussed. The outcomes of these tests are conflicting and inconclusive. The physical/chemical tests seem to be an alternative method. However, until now it has not been possible to establish the threshold concentration in urine or blood beneath which no effect has to be expected. Therefore, the interpretation of the concentration of cytotoxic drugs and/or the metabolites in the urine or blood is difficult. As long as one will not be able to provide conclusive data on the health hazards when working with cytotoxic drugs, protective measures have to be taken in order to lower the risk as much as possible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967821
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The risks of handling cytotoxic drugs (1990)
    Springer
    Pharmacy world & science 12 (1990), S. 228-235 
    Details
    ISSN: 1573-739X
    Keywords: Antineoplastic agents ; Drug compounding ; Drug contamination ; Health-care personnel ; Occupational health ; Protective devices ; Waste products
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Presuming that preparation of antineoplastic drugs without proper protection may lead to mutagenic urine (of which the effects are uncertain), one has to take great care when preparing these drugs. Apart from Norway no other country has national regulations issued by the government for handling cytostatic agents. Many organizations in various countries have made their own guidelines, which may be adapted to the situations in local hospitals. The following recommendations have been compiled after a review of the literature. They reflect a personal set of guidelines for preparation, administration and disposal of cytotoxic drugs. They are probably the minimum precautions that should be taken, and have not been approved by any committee or agency. Further precautions must first have their potential benefit weighed against probable inconvenience and additional costs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967822
    Location Call Number Expected Availability
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    Paper (German National Licenses)
    Fulltext
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