Publikationsdatum:
2004-05-29
Beschreibung:
"Cross-priming" describes the activation of naive CD8+ T cells by professional antigen-presenting cells that have acquired viral or tumor antigens from "donor" cells. Antigen transfer is believed to be mediated by donor cell-derived molecular chaperones bearing short peptide ligands generated by proteasome degradation of protein antigens. We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8+ T cell responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norbury, Christopher C -- Basta, Sameh -- Donohue, Keri B -- Tscharke, David C -- Princiotta, Michael F -- Berglund, Peter -- Gibbs, James -- Bennink, Jack R -- Yewdell, Jonathan W -- AI-056094-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 May 28;304(5675):1318-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892-0440, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166379" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Acetylcysteine/*analogs & derivatives/pharmacology
;
Animals
;
*Antigen Presentation
;
Antigens/*immunology/metabolism
;
Antigens, Viral/immunology/metabolism
;
CD8-Positive T-Lymphocytes/*immunology
;
Cell Line
;
*Cross-Priming
;
Cysteine Endopeptidases/*metabolism
;
Cysteine Proteinase Inhibitors/pharmacology
;
Endoplasmic Reticulum/metabolism
;
Humans
;
Immunization
;
Influenza A virus/immunology
;
Lymphocyte Activation
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Molecular Chaperones/metabolism
;
Multienzyme Complexes/*metabolism
;
Ovalbumin/immunology/metabolism
;
Peptide Fragments/immunology
;
Proteasome Endopeptidase Complex
;
Recombinant Fusion Proteins/immunology/metabolism
;
Vaccines/immunology
;
Vaccinia virus/genetics/physiology
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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