ISSN:
1040-0397
Keywords:
Iron (II) bathophenanthroline iodide membrane
;
Iodide PVC sensor
;
Potentiometry
;
Sequential determination of iodine and iodide
;
Povidone iodine
;
Pharmaceutical analysis
;
Flow-injection analysis
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A potentiometric sensor-based flow-injection system for determining iodide is described. The system utilizes a flow-through sandwich cell and incorporates iron (II)-tris bathophenanthroline iodide ion pair complex as an exchange site in a PVC matrix membrane. The sensor displays a fast response for 10-1 to 10-6 M iodide ion with an anionic slope of 59.1 ± 0.3 mV/concentration decade over the pH range 1 to 11. The experimental setup offers a precise, sensitive, selective and high sample throughput technique for determining iodide and iodine over a wide range of concentration. The limit of detection is 0.5 ppm iodide in a 20 μL sample. The average recovery is 99.8%, and the mean standard deviation is 0.5%. Sequential flow-injection determination of iodide and iodine in some pharmaceutical preparations containing povidone iodine is performed by sample injection in a sodium sulfate-ascorbic acid stream and monitoring of the total iodide equivalent to I- and I2. This is followed by injection of a second sample in an alkaline resorcinol stream and measuring of the iodide equivalent to I- and 1/2 I2. Iodine and iodide concentrations are calculated from the consecutive signals. The method gives results in good agreement with those obtained by the United States Pharmacopeia.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140050921
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