ISSN:
1573-6881
Keywords:
Potassium channels
;
membrane proteins
;
channel gating
;
ion permeation
;
mutagenesis
;
channel structure
;
shaker
;
TEA
;
charybdotoxin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Physics
Notes:
Abstract The voltage-activated K+ channels are members of an ion channel family that includes the voltage-activated Na+ and Ca2+ channels. These ion channels mediate the transmembrane ionic currents that are responsible for the electrical signals produced by cells. The recent cloning of numerous voltage-activated K+ channels has made it possible to combine molecular-genetic and biophysical methods to study K+ channel mechanisms. These mutagenesis-function studies are beginning to provide new information about the architecture of K+ channel proteins and how they form a voltage-gated, K+-selective pore.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00785815
Permalink
