ISSN:
0021-8995
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
,
Physics
Notes:
Various polymeric prodrugs of pholcodine were prepared by covalently linking a substrate ester of the hydroxylic drug to cellulosic derivatives. The ester derivatives of the drug were chosen so that the resulting insoluble cellulosic prodrugs became substrates of α-chymotrypsin. The hydrolysis of such compounds was studied for various spacer arms in conditions simulating the intestinal medium. A theoretical model was developed to describe the enzymatic catalysis of this hydrolysis, taking into account the adsorption of the enzyme onto the polymer, the hydrolysis reaction, and the enzyme denaturation. The resulting equations using independently determined parameter values such as the Langmuir adsorption constants, the enzyme denaturation constants, and the initial hydrolysis rate constant successfully correlated with the experimental data.
Additional Material:
11 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/app.1986.070320101
Permalink
