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  • Polymer and Materials Science  (4)
  • [abr] HB-EGF; heparin-binding epidermal growth factor
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 185 (1992), S. 103-109 
    ISSN: 0006-291X
    Keywords: [abr] EGF; epidermal growth factor ; [abr] HB-EGF; heparin-binding epidermal growth factor ; [abr] LTR; long terminal repeat ; [abr] MMTV; mouse mammary tumor virus ; [abr] PCR; polymerase chain reaction ; [abr] SDGF; schwannoma-derived growth factor ; [abr] TGF; transforming growth factor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 185 (1992), S. 103-109 
    ISSN: 0006-291X
    Keywords: [abr] EGF; epidermal growth factor ; [abr] HB-EGF; heparin-binding epidermal growth factor ; [abr] LTR; long terminal repeat ; [abr] MMTV; mouse mammary tumor virus ; [abr] PCR; polymerase chain reaction ; [abr] SDGF; schwannoma-derived growth factor ; [abr] TGF; transforming growth factor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 12 (1974), S. 221-224 
    ISSN: 0360-6384
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 26 (1987), S. 625-632 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The effect of LiCl, NaCl, and CsCl as univalent salts, and of CaCl2, ZnCl2, and MgCl2 as divalent salts, on the α and antiparallel β-sheet, and random conformations of poly(L-lysine) (PLL), in water at room temperature were examined by means of CD and compared quantitatively on the basis of elliptical strength at the maximal peak. Changes in the α-helical and antiparallel β-sheet helical conformations of PLL were markedly dependent on the salt concentrations of LiCl, NaCl, and CsCl, which induced decreases in negative intensity in that order. The CD spectrum of the random conformation, the most disordered form, displayed positive cotton effect in concentrations of these salts up to 3.0M and a negative peak in concentrations of 6.0M. The effect of these salts on the random conformation of PLL was stronger than that on the α- and β-conformations in higher concentrations. The CD spectrum of the random conformation in the presence of CaCl2, ZnCl2, and MgCl2, on the other hand, showed negative cotton effect in salt concentrations as low as 3.0M. It was impossible, however, to measure the effect on α- and β-conformations of ZnCl2 and MgCl2 above concentrations of 10 mM because of a solubility problem with salts in alkaline solution.
    Additional Material: 5 Ill.
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  • 5
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 15 (1981), S. 553-563 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: With a view to developing biomaterials for semipermanent substitution, we have studied a composite material constituted with collagen and a synthetic polymer which possesses high tissue compatibility. This collagen - synthetic polymer composite was applied as a support for immobilization of enzymes for the purpose of providing a material surface with biological function. The enzymes, urokinase and trypsin, were successfully bound to the collagen membrane layer which had been activated by acyl azide formation of its carboxyl groups. The enzyme-bearing composite material showed excellent catalytic activity toward a protein substrate as well as a low-molecular-weight synthetic substrate. The immobilized urokinase was characterized enzymatically and compared with native urokinase. The apparent affinity of immobilized urokinase for the substrate was slightly decreased, but its intrinsic kinetic properties were not significantly affected. No decrease in its esterase activity was observed both on repeated use and on long-term storage, and its fibrinolytic activity was stable on heat or disinfection treatment. When this urokinase-bearing composite material was applied into rabbit blood vessels, its in vivo fibrinolytic activity was maintained. Thus, enzyme - collagen - synthetic polymer composites may find wide application for biomaterials and artificial organs as functional biomaterials.
    Additional Material: 7 Ill.
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  • 6
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 23 (1989), S. 1115-1130 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: In order to study the effects of factors governing the bioabsorption rate of polylactides, implantation tests were carried out in rabbits using various samples (20 × 10 × 2 mm3) differing in their chemical composition, residual monomer content, and molecular orientation. Copolymer samples with a higher lactic acid content showed a lower rate of absorption, whereas those with a higher unreacted monomer content were absorbed faster and showed a more drastic decrease in molecular weight. In contrast, degradation of the purified polymers was slow; the purified poly-L-lactide showed no weight change and a 50% reduction in molecular weight after 6 months of implantation. Scanning electron microscopy of the samples containing monomers showed a microporous structure extending from the surface to the inner region a few days after implantation, whereas the purified poly-L-lactide did not exhibit a microporous structural change even after 10 months of implantation.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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