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The pharmacology of α-bungarotoxin-resistant acetylcholine receptors on an identified cockroach motoneurone (1993)

David, J. A. ; Pitman, R. M.

Springer

Journal of comparative physiology 172 (1993), S. 359-368

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ISSN: 1432-1351

Keywords: Acetylcholine receptors ; Muscarinic ; Nicotinic ; Cockroach ; Periplaneta americana

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The effects of a number of cholinergic agonists and antagonists have been examined on the cell body of the fast coxal depressor (Df) of the cockroach Periplaneta americana using voltage-clamp techniques. Acetylcholine (ACh), when applied to this neurone voltage-clamped at its normal resting potential, results in the generation of an inward current through the activation of receptors which are blocked by α-bungarotoxin (α-bgt). At more depolarized membrane potentials acetylcholine induces an inward current which is strongly voltage-dependent and which is insensitive to α-bgt. An α-bgt-resistant current is also induced by the application of a number of cholinergic agonists. In order of potency these are: decamethonium〉oxotremorine = McN-A-343 = (+)-muscarine = arecaidine propargyl ester 〉nicotine 〉ACh. This α-bgt-resistant response to cholinergic agonists is blocked by a range of antagonists. In order of potency these are : decamethonium 〉pirenzipine 〉quinuclidinyl benzilate = atropine = p-f-hexahydro-sila-difenidol = dexetimide 〉scopolamine = methoctramine. The receptors mediating this response have been termed ‘mixed cholinergic’ due to their sensitivity to both nicotinic and muscarinic ligands. Pharmacological similarities between these ‘mixed’ receptors and binding components found in high speed supernatant fractions of insect nervous tissue are discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00216618

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A biomechanical study of tendon adhesion reduction using a biodegradable barrier in a rabbit model (1990)

Meislin, Robert J. ; Wiseman, David M. ; Alexander, Harold ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Applied Biomaterials 1 (1990), S. 13-19

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ISSN: 1045-4861

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine , Technology

Notes: Adhesion formation associated with tendon surgery is a widespread problem in which a healing tendon becomes adherent via scar tissue to surrounding structures such as bone, muscle, skin, tendon sheath, or other tendons. A model is described in which adhesions were generated reproducibly between the plantaris and Achilles tendons of the rabbit using a partial tenotomy, a Bunnel suture, and immobilization. Using this model, the effect of an absorbable barrier, INTERCEED (TC7),INTERCEED (TC7) Absorbable Adhesion Barrier is a trademark of Johnson & Johnson Patient Care Inc. on adhesion formation was investigated. This material, which is a fabric comprised of oxidized regenerated cellulose, was found to diminish significantly the extent and severity of intertendinous adhesions, assessed both mechanically and histologically. No evidence of a foreign body reaction was observed.

Additional Material: 6 Ill.