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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 53 (1993), S. S75 
    ISSN: 1432-0827
    Keywords: Microdamage ; Remodeling ; Fatigue ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary This paper reviews the direct and indirect evidence for and against the idea that bone remodeling repairs fatigue damage. It defines experiments that should be performed to determine whether the accumulation and repair of fatigue damage is relevant to the pathogenesis of osteoporotic fracture. The experimental evidence favors the hypothesis that microdamage evokes local remodeling. The data suggest that the balance between the microdamage burden and bone repair is nearly constant. The indirect evidence comes from clinical observations that show positive relationships between depressed bone formation rate or prolonged remodeling period with bone fracture. More compelling indirect evidence comes from studies in which bone remodeling was pharmaceutically depressed, and fracture incidence rose in direct proportion. Data on microdamage accumulation were not collected in these studies. Conversely, some experimental evidence disputes a direct relationship between fatigue microdamage and repair. In these studies, increased amounts of bone microdamage in hyperadrenocortical dogs, and in irradiated dogs, could not be demonstrated even though bone fragility increased without associated osteopenia. Finally, the indirect evidence that argues that microdamage does not initiate repair is based on inference and does not provide an adequate test of the hypothesis. In balance, the current body of evidence favors the contention that bone remodeling repairs fatigue damage and thereby prevents fracture. Future studies should verify that microdamage accumulates when bone fracture occurs in conjunction with depressed remodeling activation frequency.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-9686
    Keywords: Stress fracture ; Bone strain ; Fatigue ; Aging ; Exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Muscular fatigue in the training athlete or military recruit has been hypothesized to cause increased bone strain that may contribute to the development of a stress fracture. Under normal circumstances, muscles exert a protective effect by contracting to reduce bending strains on cortical bone surfaces. In vivo strain studies in dogs show that muscle fatigue following strenuous exercise elevates bone strain and changes strain distribution. However, a similar experiment has yet to be performed in humans. The purpose of this work was to test the hypothesis in humans that strenuous fatiguing exercise causes an elevation in bone strain. It was also hypothesized that this elevation is greater in younger people than in older people due to the decline in muscle strength and endurance that normally occurs with age. To test these hypotheses, strain in the tibiae of seven human volunteers was measured during walking before and after a period of fatiguing exercise. Neither hypothesis was sustained. Post-hoc analysis of the strain data suggests that strain rate increases after fatigue with a greater increase in younger as opposed to older persons. Although not conclusive, this suggests that it is strain rate, rather than strain magnitude, that may be causal for stress fracture. © 1998 Biomedical Engineering Society. PAC98: 8745Dr, 8745Bp, 0180+b
    Type of Medium: Electronic Resource
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  • 3
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    Arizona Board of Regents | Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  Viktor Hamburger collection, Box 2, Folder 60, Paul Weiss, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: Invitation to dinner.
    Description: Typewritten carbon copy of original letter.
    Description: 1-page letter
    Description: Correspondence
    Keywords: People
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
    Format: image/tiff
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  • 4
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    Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  Viktor Hamburger collection, Box 2, Folder 46, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: General updates
    Description: Correspondence
    Keywords: People
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
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  • 5
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    Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  Viktor Hamburger collection, Box 2, Folder 46, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: News on travels, microscope, anatomy course
    Description: Correspondence
    Keywords: People ; Tools
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
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  • 6
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    Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  Viktor Hamburger collection, Box 2, Folder 46, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: Update on zoology course. Personal updates
    Description: Correspondence
    Keywords: People
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
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  • 7
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    Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  Viktor Hamburger collection, Box 2, Folder 46, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: General updates
    Description: Correspondence
    Keywords: People
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
    Format: image/tiff
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  • 8
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    Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  Viktor Hamburger collection, Box 2, Folder 46, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: Travel and personnel changes
    Description: Correspondence
    Keywords: People
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
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  • 9
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    Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  Viktor Hamburger collection, Box 2, Folder 46, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: Personnel discussions
    Description: Correspondence
    Keywords: People
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
    Format: image/tiff
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  • 10
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    Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  Viktor Hamburger collection, Box 2, Folder 46, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: Updates on courses and teaching
    Description: Correspondence
    Keywords: People
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
    Format: image/tiff
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