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  • Pars distalis  (3)
  • House  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 113 (1971), S. 29-38 
    ISSN: 1432-0878
    Keywords: Pars distalis ; STH cells ; Hepatectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An electron microscopic analysis was performed on the pars distalis of the hypophysis of hepatectomized mice. Intact and sham operated mice served as controls. The STH cells presented striking changes that were most intense and widespread in those animals sacrificed at midnight of the second day after hepatectomy. These changes can be summarized as follows: 1) Hypertrophy of the Golgi complex with increased number of immature granules within the Golgi zone. This change appeared also in otherwise unmodified STH cells. 2) Strong dilatation of the endoplasmic reticulum whose cisternae contained much electron dense material. 3) Granules with partially diminished electron density, some of them in spatial relation with the plasma membrane and others swelling and bursting within the cytoplasm. All transitions between unchanged 350–400 mμ granules and extremely altered ones, were seen. 4) Release sites, characterized by dense zones in the plasmalemma, close to aggregates of electron lucent microvesicles, and almost empty granule membranes. 5) Increase in the density of the mitochondria which appeared grouped near the Golgi zone. 6) Increase in the number of large lysosomes of the autophagic vacuole type. 7) Irregular nuclear outlines. These data suggest increased synthesis and release of growth hormone in STH cells stimulated by hepatectomy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 118 (1971), S. 525-531 
    ISSN: 1432-0878
    Keywords: Hypophysis ; Mouse ; Pars distalis ; STH cells ; Hepatomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An electron microscopic analysis was performed on the pars distalis of the hypophysis of mice bearing transplanted hepatomas. Normal mice served as controls. In animals bearing a fast growing as well as in those bearing a slow growing hepatoma, the STH cells presented changes indicating increased release and synthesis of its secretory product. These changes can be summarized as follows: 1) Increased number of granuledepleted STH cells which were very irregular in size and shape. 2) Very irregular and sometimes bizarre nuclei. 3) Plasma membranes irregular and convoluted. 4) Increased quantity of endoplasmic reticulum which appeared sometimes dilated and contained material of varying electron density. 5) Abundant, irregular and frequently ramified mitochondria. 6) Hypertrophic Golgi system with increased number of microvesicles. 7) Increased number of large lysosomes of different type. 8) Increased number of fat droplets.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 144 (1973), S. 31-35 
    ISSN: 1432-0878
    Keywords: Pars distalis ; House ; STH cells ; Castration ; Hepatectomy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An electron microscopic study aimed at differentiation between “castration gonadotrophs” and “posthepatectomy STH cells” was performed on the pars distalis of the pituitary of castrated male mice, after partial hepatectomy. The ultrastructural features observed permit the distinction of both cell types. In the present experiments some remarkable ultrastructural changes, other than those described in a previous report, have been found in STH cells of hepatectomized mice with or without previous castration. Most of them contained masses of heterogeneous electron density, suggesting fusion of granules. These masses and some secretion granules were observed close to the plasma membrane, apparently in the process of discharging material into the pericapillary space. Granular extrusion was more frequent than normally. An increased number of lysosomes, probably related to the digestion of overproduced secretion material, was evident. The appearance of concentric lamellar formations might be related to an increase in cell movements. STH cells with severe cytoplasmic damage were also found, indicating an increased rate of cell loss.
    Type of Medium: Electronic Resource
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