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  • 1
    Electronic Resource
    Electronic Resource
    Charge heterogeneity of macrophage migration inhibitory factor (MIF) in human liver and breast tissue (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 2010-2013 
    Details
    ISSN: 0173-0835
    Keywords: Breast biopsy ; Two-dimensional polyacrylamide gel electrophoresis ; Macrophage migration inhibitory factor ; Liver biopsy ; Breast cell line ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Macrophage migration inhibitory factor (MIF) is an ubiquitous protein playing various immunological and hormonal roles. Theoretical electrophoretic coordinates calculated from protein sequence in the SWISS-PROT database (AC P14174) are 12 kDa and pI 8.24. Using two-dimensional (2-D) immunoblotting, we have detected isoelectric forms at ca. 11.9 kDa, with pI values of 7.8 and 6.98 in human liver tissue, breast tissue and a cell line and in preparations of human MIF expressed in E. coli. This evidence suggests that MIF charge heterogeneity originates from a post-translational modification not requiring euka-ryote-specific enzymes. We have also detected in human liver a minor immunoreactive spot at pI 6.23, which coincides with the MIF spot in the liver map in SWISS-2DPAGE. The pI 6.23 isoform also conceivably derives from post-translational modification, as MIF is known to be encoded in the human genome by a single copy gene.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150191120
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  • 2
    Electronic Resource
    Electronic Resource
    Protein expression profiles in human breast ductal carcinoma and histologically normal tissue (1997)
    Weinheim : Wiley-Blackwell
    Electrophoresis 18 (1997), S. 2832-2841 
    Details
    ISSN: 0173-0835
    Keywords: Ductal breast carcinoma ; Breast biopsy ; Two-dimensional polyacrylamide gel electrophoresis ; Reference map ; Immobilized pH gradient ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Reference two-dimensional (2-D) gels are presented for human breast ductal carcinoma and histologically normal tissue. Whole biopsy fragments were analyzed, including epithelial and nonepithelial components. Thirty-five spots have been assigned by gel matching to the human liver SWISS-2DPAGE reference map and/or to the human primary keratinocyte IPG map from the Danish Center for Human Genome. N-terminal microsequencing was applied to confirm randomly chosen matching assignments and to identify six new spots. Protein expression profiles in ductal carcinoma and in normal breast tissue appeared to be similar, except for a pattern consisting of 32 spots, which were highly expressed in all carcinoma specimens, and less intense and occasionally undetectable in normal tissue. This difference was statistically significant. Assignment has been obtained for several spots, namely GRP94, GRP78, GRP75, mitochondrial HSP60, calreticulin, protein disulfide isomerase, peptidyl-prolyl cis-trans isomerase, collagen-binding protein 2, fructose bisphosphate aldolase, glyceraldehyde-3-phosphate dehydrogenase, thioredoxin, cytochrome c oxidase VA subunit, tubulin β isoform and macrophage migration inhibitory factor (MIF). The cancer- and tissue-specificity of the described pattern was assessed by matching to the Swiss-2DPAGE human liver, hepatoma, lymphoma, erythroleukemia reference maps. The pattern of 32 spots was found to be indicative of epithelial neoplasia.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150181519
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  • 3
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    Speleothem U/Th age constraints for the Last Glacial conditions in the Apuan Alps, northwestern Italy (2019)
    Details
    Publication Date: 2021-06-16
    Description: During the Quaternary several glaciations occurred in the mountain regions around the Mediterranean and, in recent years, new ages have better constrained their timing. However, this is not the case for the Apuan Alps, a high-rainfall mountain chain adjacent to the Mediterranean Sea. Here, in spite of the widespread evidence for glaciers, the complete lack of geochronological information hinders our understanding of glaciation history. In this paper, we utilize speleothem ages to better constrain the timing of these glacial features. We re-examine 293 uranium‑thorium ages from 19 speleothems collected in five caves at different elevations. After a period of very low growth between 160 and 132 ka, the analysed speleothems grew almost continuously to ~75 ka, this period was followed by intermittent growth with lower deposition rate and presence of hiatuses until ~12.5/12 ka. This is consistent with an ice coverage persisting over the Apuan Alps, inhibiting or interrupting the growth of speleothems via the limited availability of groundwater and the scarcity/absence of soils. This interval is much greater than the time interval that has previously been attributed to the existence of glaciers on the Apuan Alps, which has been assumed to be restricted to Marine Isotope Stage (MIS) 2. Instead, ice cover probably also appeared in the Apuan Alps during MIS 4. The phase of restarting of growth, which may implies the definitive or substantial glacier melts seem to predate the Holocene
    Description: ARCA project “Arctic: present climatic change and past extreme events” founded by the Italian Ministry of Education, Universities and Research (MIUR); Australian Research Council Discovery Projects grant DP110102185; Palaeoclimatic palaeoenvironmental evolution of the Apuan area since the Last Glacial Maximum, Pisa University; Clima ed eventi alluvionali estremi in Versilia: integrazione di nuove tecniche geoarcheologiche, geomorfologiche, geochimiche e simulazioni numeriche, Fondazione Cassa di Risparmio di Lucca Call 2016
    Description: Published
    Description: 62-71
    Description: 5A. Paleoclima e ricerche polari
    Description: JCR Journal
    Keywords: speleothem ; glacier ; Apuan Alps ; MIS2 ; MIS3 ; MIS4 ; Paleoclima
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
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    The 4.2 ka event in the central Mediterranean: new data from a Corchia speleothem (Apuan Alps, central Italy) (2019)
    Details
    Publication Date: 2019-01-29
    Description: We present new data on the 4.2 ka event in the central Mediterranean from Corchia Cave (Tuscany, central Italy) stalagmite CC27. The stalagmite was analyzed for stable isotopes (delta13C and delta18O) and trace elements (Mg, U, P, Y), with all proxies showing a coherent phase of reduced cave recharge between ca. 4.5 and 4.1 ka BP. Based on the current climatological data on cyclogenesis, the reduction in cave recharge is considered to be associated with the weakening of the cyclone center located in the Gulf of Genoa in response to reduced advection of air masses from the Atlantic during winter. These conditions, which closely resemble a positive North Atlantic Oscillation (NAO) type of configuration, are associated with cooler and wetter summers with reduced sea warming, which reduced the western Mediterranean evaporation during autumn–early winter, further reducing precipitation.
    Description: ARCA project “Arctic: present climatic change and past extreme events” funded by the Italian Ministry of Education Universities and Research (MIUR); Australian Research Council Discovery Project DP160102969; Climate and alluvial event in Versilia: integration of Geoarcheological, Geomorphological, Geochemical data and numerical simulations Fondazione Cassa di Risparmio di Lucca; PRA-2018-41 Georisorse e Ambiente” funded by the University of Pisa
    Description: Published
    Description: 135-151
    Description: 5A. Paleoclima e ricerche polari
    Description: JCR Journal
    Keywords: speleothem ; 4.2 ka BP event ; isotopes ; trace elements ; Paleoclima
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 5
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    Geochemical characteristics of the infilling of ground wedges at Puerto Deseado (Santa Cruz, Argentina): palaeoenvironmental and chronological implications (2019)
    Details
    Publication Date: 2019-03-27
    Description: Ground wedge structures of cryogenic origin are common in the Quaternary sediments along the coast of the Patagonia, and their formation is related to climatic cold events experienced by this area in the Late Quaternary. The infilling sediments of two wedges generations were analyzed in the area of Puerto Deseado. Bulk chemistry (major elements), X-ray diffraction (XRD), morphoscopic observations with Scanning Electronic Microscope (SEM) and chemical analyses of volcanic glass shards were undertaken to provide indications about infilling sediment provenience, along with chronological constraint for wedge formation. Bulk chemistry and XRD patterns indicate a significant SiO2- enriched composition of the sediment infilling compared to the most of the loess deposits of the North Argentina and the present day dust originated in Patagonia. This was interpreted as due to the nature of the bedrock present over the Deseado Massif. SEM morphoscopic characteristics of glass shards evidence typical aeolian reworking features, with impact structures and indented edges of the volcanic fragments. Chemical analyses of the glass shards indicate that they were probably generated by the H0 eruption (17,300-17,400 cal yr BP) of the Hudson volcano. Volcanological data indicate that H0 eruption dispersed toward NE, but volcanic glasses were available for reworking due to a WNW component in the western wind direction. Over the Deseado Massif structural high the glass shards mixed with sediments enriched in SiO2, and were eventually deflated further to SE reaching the present coastal area and infilling the frost cracks. The age of the glass shards (17,300-17,400 cal yr BP) and that of the sandy layer affected by cryogenic structures (14,670±750 yr BP) well constrain to the Late Glacial both wedge generations.
    Description: Progetto Ateneo 2007, University of Pisa; PRIN2008, MIUR
    Description: Published
    Description: 130-144
    Description: 5A. Ricerche polari e paleoclima
    Description: JCR Journal
    Keywords: Wedge structure ; geochemistry ; Quaternary sediments ; Patagonia ; Paleoclima
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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