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  • 1
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    Handbook of Climate Change and Agroecosystems : The Agricultural Model Intercomparison and Improvement Project (AgMIP) Integrated Crop and Economic Assessments; Parts 1 and 2 (2015)
    London : Imperial College Press
    Details
    Keywords: climate change ; agriculture
    Description / Table of Contents: The Agricultural Model Intercomparison and Improvement Project: Phase I Activities by a Global Community of Science (Cynthia Rosenzweig, James W Jones, Jerry L Hatfield, John M Antle, Alexander C Ruane, and Carolyn Z Mutter) --- AgMIP's Transdisciplinary Agricultural Systems Approach to Regional Integrated Assessment of Climate Impacts, Vulnerability, and Adaptation (John M Antle, Roberto O Valdivia, Kenneth J Boote, Sander Janssen, James W Jones, Cheryl H Porter, Cynthia Rosenzweig, Alexander C Ruane, and Peter J Thorburn) --- AgMIP Climate Data and Scenarios for Integrated Assessment (Alexander C Ruane, Jonathan M Winter, Sonali P McDermid, and Nicholas I Hudson) --- Cropping Systems Modeling in AgMIP: A New Protocol-Driven Approach for Regional Integrated Assessments (Peter J Thorburn, Kenneth J Boote, John N G Hargreaves, Perry L Poulton, and James W Jones) --- Representative Agricultural Pathways and Scenarios for Regional Integrated Assessment of Climate Change Impacts, Vulnerability, and Adaptation (Roberto O Valdivia, John M Antle, Cynthia Rosenzweig, Alexander C Ruane, Joost Vervoort, Muhammad Ashfaq, Ibrahima Hathie, Sabine Homann-Kee Tui, Richard Mulwa, Charles Nhemachena, Paramasivam Ponnusamy, Herath Rasnayaka, and Harbir Singh) --- Data Interoperability Tools for Regional Integrated Assessments (Cheryl H Porter, Chris Villalobos, Dean Holzworth, Roger Nelson, Jefffrey W White, Ioannis N Athanasiadis, Meng Zhang, Sander Janssen, Rob Knapen, James W Jones, Kenneth J Boote, John Hargreaves, and John M Antle) --- The AgMIP GRIDded Crop Modeling Initiative (AgGRID) and the Global Gridded Crop Model Intercomparison (GGCMI) (Joshua Elliott and Christoph Müller) --- The AgMIP Coordinated Climate-Crop Modeling Project (C3MP): Methods and Protocols (Sonali P McDermid, Alexander C Ruane, Cynthia Rosenzweig, Nicholas I Hudson, Monica D Morales, Prabodha Agalawatte, Shakeel Ahmad, L R Ahuja, Istiqlal Amien, Saseendran S Anapalli, Jakarat Anothai, Senthold Asseng, Jody Biggs, Federico Bert, Patrick Bertuzzi, Virender S Bhatia, Marco Bindi, Ian Broad, Davide Cammarano, Ramiro Carretero, Ashfaq Ahmad Chattha, Uran Chung, Stephanie Debats, Paola Deligios, Giacomo De Sanctis, Thanda Dhliwayo, Benjamin Dumont, Lyndon Estes, Frank Ewert, Roberto Ferrise, Thomas Gaiser, Guillermo Garcia, Sika Gbegbelegbe, Vellingiri Geethalakshmi, Edward Gerardeaux, Richard Goldberg, Brian Grant, Edgardo Guevara, Jonathan Hickman, Holger Hoffmann, Huanping Huang, Jamshad Hussain, Flavio Barbosa Justino, Asha S Karunaratne, Ann-Kristin Koehler, Patrice K Kouakou, Soora Naresh Kumar, Arunachalam Lakshmanan, Mark Lieffering, Xiaomao Lin, Qunying Luo, Graciela Magrin, Marco Mancini, Fabio Ricardo Marin, Anna Dalla Marta, Yuji Masutomi, Theodoros Mavromatis, Greg McLean, Santiago Meira, Monoranjan Mohanty, Marco Moriondo, Wajid Nasim, Lamyaa Negm, Francesca Orlando, Simone Orlandini, Isik Ozturk, Helena Maria Soares Pinto, Guillermo Podesta, Zhiming Qi, Johanna Ramarohetra, Muhammad Habib ur Rahman, Helene Raynal, Gabriel Rodriguez, Reimund Rötter, Vaishali Sharda, Lu Shuo, Ward Smith, Val Snow, Afshin Soltani, K Srinivas, Benjamin Sultan, Dillip Kumar Swain, Fulu Tao, Kindie Tesfaye, Maria I Travasso, Giacomo Trombi, Alex Topaj, Eline Vanuytrecht, Federico E Viscarra, Syed Aftab Wajid, Enli Wang, Hong Wang, Jing Wang, Erandika Wijekoon, Lee Byun-Woo, Yang Xiaoguang, Ban Ho Young, Jin I Yun, Zhigan Zhao, and Lareef Zubair) --- Uncertainty in Agricultural Impact Assessment (Daniel Wallach, Linda O Mearns, Michael Rivington, John M Antle, and Alexander C Ruane) --- Uncertainties in Scaling-Up Crop Models for Large-Area Climate Change Impact Assessments (Frank Ewert, Lenny G J van Bussel, Gang Zhao, Holger Hoffmann, Thomas Gaiser, Xenia Specka, Claas Nendel, Kurt-Christian Kersebaum, Carmen Sosa, Elisabet Lewan, Jagadeesh Yeluripati, Matthias Kuhnert, Fulu Tao, Reimund Rötter, Julie Constantin, Helene Raynal, Daniel Wallach, Edmar Teixeira, Balasz Grosz, Michaela Bach, Luca Doro, Pier Paolo Roggero, Zhigan Zhao, Enli Wang, Ralf Kiese, Edwin Haas, Henrik Eckersten, Giacomo Trombi, Marco Bindi, Christian Klein, Christian Biernath, Florian Heinlein, Eckart Priesack, Davide Cammarano, Senthold Asseng, Joshua Elliott, Michael Glotter, Bruno Basso, Guillermo A Baigorria, Consuelo C Romero, and Marco Moriondo) --- Statistical Analysis of Large Simulated Yield Datasets for Studying Climate Change Effects (David Makowski, Senthold Asseng, Frank Ewert, Simona Bassu, Jean-Louis Durand, Pierre Martre, Myriam Adam, Pramod K Aggarwal, Carlos Angulo, Christian Baron, Bruno Basso, Patrick Bertuzzi, Christian Biernath, Hendrik Boogaard, Kenneth J Boote, Nadine Brisson, Davide Cammarano, Andrew J Challinor, Sjakk J G Conijn, Marc Corbeels, Delphine Deryng, Giacomo De Sanctis, Jordi Doltra, Sebastian Gayler, Richard Goldberg, Patricio Grassini, Jerry L Hatfield, Lee Heng, Steven Hoek, Josh Hooker, Tony L A Hunt, Joachim Ingwersen, Cesar Izaurralde, Raymond E E Jongschaap, James W Jones, Armen R Kemanian, Christian Kersebaum, Soo-Hyung Kim, Jon Lizaso, Christoph Müller, Naresh S Kumar, Claas Nendel, Garry J O'Leary, Jorgen E Olesen, Tom M Osborne, Taru Palosuo, Maria V Pravia, Eckart Priesack, Dominique Ripoche, Cynthia Rosenzweig, Alexander C Ruane, Fredirico Sau, Mickhail A Semenov, Iurii Shcherbak, Pasquale Steduto, Claudio Stöckle, Pierre Stratonovitch, Thilo Streck, Iwan Supit, Fulu Tao, Edmar I Teixeira, Peter Thorburn, Denis Timlin, Maria Travasso, Reimund Rötter, Katharina Waha, Daniel Wallach, Jeffrey W White, Jimmy R Williams, and Joost Wolf) --- Crop Diseases and Climate Change in the AgMIP Framework (Ariena H C van Bruggen, James W Jones, Jose Mauricio C Fernandes, Karen Garrett, and Kenneth J Boote) --- Perspectives on Climate Effects on Agriculture: The International Efforts of AgMIP in Sub-Saharan Africa (Job Kihara, Dilys S MacCarthy, Andre Bationo, Saidou Koala, Jonathan Hickman, Jawoo Koo, Charles Vanya, Samuel Adiku, Yacob Beletse, Patricia Masikate, Karuturi P C Rao, Carolyn Z Mutter, Cynthia Rosenzweig, and James W Jones) --- Climate Change Impacts on West African Agriculture: An Integrated Regional Assessment (CIWARA) (Samuel G K Adiku, Dilys S MacCarthy, Ibrahima Hathie, Madina Diancoumba, Bright S Freduah, Joseph Amikuzuno, P C Sibiry Traore, Seydou Traore, Eric Koomson, Alhassane Agali, Jon I Lizaso, Dougbedji Fatondji, Myriam Adams, Lodoun Tigana, Daouda Z Diarra, Ousmane N'diaye, and Roberto O Valdivia) --- Impacts of Climate Variability and Change on Agricultural Systems in East Africa (Karuturi P C Rao, Gummadi Sridhar, Richard M Mulwa, Mary N Kilavi, Anthony Esilaba, Ioannis N Athanasiadis, and Roberto O Valdivia) --- Projected Impacts of Climate Change Scenarios on the Production of Maize in Southern Africa: An Integrated Assessment Case Study of the Bethlehem District, Central Free State, South Africa (Yacob G Beletse, Wiltrud Durand, Charles Nhemachena, Olivier Crespo, Weldemichael A Tesfuhuney, Matthew R Jones, Mogos Y Teweldemedhin, Sunshine M Gamedze, Pontsho M Bonolo, Syanda Jonas, SueWalker, Patrick Gwimbi, Thembeka N Mpuisang, Davide Cammarano, and Roberto O Valdivia) --- Crop-Livestock Intensification in the Face of Climate Change: Exploring Opportunities to Reduce Risk and Increase Resilience in Southern Africa by Using an Integrated Multi-modeling Approach (Patricia Masikati, Sabine Homann-Kee Tui, Katrien Descheemaeker, Olivier Crespo, Sue Walker, Christopher J Lennard, Lieven Claessens, Arthur C Gama, Sebastiao Famba, Andre F van Rooyen, and Roberto O Valdivia) --- Integrated Assessments of the Impacts of Climate Change on Agriculture: An Overview of AgMIP Regional Research in South Asia (Sonali P McDermid, Guntuku Dileepkumar, K M Dakshina Murthy, S Nedumaran, Piara Singh, Chukka Srinivasa, B Gangwar, N Subash, Ashfaq Ahmad, Lareef Zubair, and S P Nissanka) --- Impact of Climate Change on the Rice–Wheat Cropping System of Pakistan (Ashfaq Ahmad, Muhammad Ashfaq, Ghulam Rasul, Syed Aftab Wajid, Tasneem Khaliq, Fahd Rasul, Umer Saeed, Muhammad Habib ur Rahman, Jamshad Hussain, Irfan Ahmad Baig, Syed Asif Ali Naqvi, Syed Ahsan Ali Bokhari, Shakeel Ahmad, Wajid Naseem, Gerrit Hoogenboom, and Roberto O Valdivia) --- Integrated Climate Change Assessment through Linking Crop Simulation with Economic Modeling — Results from the Indo-Gangetic Basin (Nataraja Subash, Babooji Gangwar, Harbir Singh, Guillermo Baigorria, Alok Kumar Sikka, and Roberto O Valdivia) --- Integrated Assessment of Climate Change Impacts on Maize Farms and Farm Household Incomes in South India: A Case Study from Tamil Nadu (Paramasivam Ponnusamy, Geethalakshmi Vellingiri, Raji Reddy Danda, Lakshmanan Arunachalam, Dakshina Murthy, Sunandini Prema, Sreenivas Gade, Sonali P McDermid, and Roberto O Valdivia) --- Climate Change Impacts on Rice Farming Systems in Northwestern Sri Lanka (Lareef Zubair, Sarath P Nissanka, W M W Weerakoon, Dumindu I Herath, Asha S Karunaratne, A S M Prabodha, M B Agalawatte, Rasnayaka M Herath, S Zeenas Yahiya, B V R Punyawardene, Janan Vishwanathan, Punya Delpitiya, A Erandika N Wijekoon, Janaka Gunaratna, Sewwandhi S K Chandrasekara, P Wickramagamage, K D N Weerasinghe, Champa M Navaratne, Ruchika S Perera, Asela I Gunesekara, G M Pradeep Kumara, Daniel Wallach, Roberto O Valdivia, and Sonali P McDermid) --- AgMIP Regional Activities in a Global Framework: The Brazil Experience (Eduardo D Assad, Fábio R Marin, Roberto O Valdivia, and Cynthia Rosenzweig) --- AgMIP Regional Activities in a Global Framework: The China Experience (Fulu Tao and Erda Lin) --- AgMIP Training in Multiple Crop Models and Tools (Kenneth J Boote, Cheryl H Porter, John Hargreaves, Gerrit Hoogenboom, Peter Thorburn, and Carolyn Mutter) --- Major Findings and Future Activities (Cynthia Rosenzweig and Daniel Hillel)
    Pages: Online-Ressource (XXVII, 525 pages (part 1); XXIII, 580 pages (part 2))
    ISBN: 9781783265633
    URL: http://www.worldscientific.com/worldscibooks/10.1142/p970
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Impact of Climate Change on Maize Yield in Central and Northern Greece: A Simulation Study with Ceres-Maize (1997)
    Springer
    Mitigation and adaptation strategies for global change 1 (1997), S. 251-271 
    Details
    ISSN: 1573-1596
    Keywords: Greece ; maize ; climate change ; CO2 effects ; adaptation ; crop simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract The potential impacts of climate change on the phenology and yield of two maize varieties in Greece were studied. Three sites representing the central and northern agricultural regions were selected: Karditsa, Naoussa and Xanthi. The CERES-Maize model, embedded in the Decision Support System for Agrotechnology Transfer (DSSAT 3.0), was used for the crop simulations, with current and possible future management practices. Equilibrium doubled CO2 climate change scenarios were derived from the GISS, GFDL, and UKMO general circulation models (GCMs); a transient scenario was developed from the GISS GCM transient run A. These scenarios predict consistent increases in air temperature, small increases in solar radiation and precipitation changes that vary considerably over the study regions in Greece. Physiological effects of CO2 on crop growth and yield were simulated. Under present management practices, the climate change scenarios generally resulted in decreases in maize yield due to reduced duration of the growing period at all sites. Adaptation analyses showed that mitigation of climate change effects may be achieved through earlier sowing dates and the use of new maize varieties. Varieties with higher kernel-filling rates, currently restricted to the central regions, could be extended to the northern regions of Greece. In the central regions, new maize varieties with longer grain-filling periods might be needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:MITI.0000018044.48957.28
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  • 3
    Electronic Resource
    Electronic Resource
    Impacts of Global Climate Change on Mediterranean Agrigulture: Current Methodologies and Future Directions. An Introductory Essay (1997)
    Springer
    Mitigation and adaptation strategies for global change 1 (1997), S. 219-232 
    Details
    ISSN: 1573-1596
    Keywords: climate change ; mediterranean region ; agriculture ; cereal production ; impact assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract Current trends in Mediterranean agriculture reveal differences between the Northern and Southern Mediterranean countries as related to population growth, land and water use, and food supply and demand. The changes in temperature and precipitation predicted by general circulation models for the Mediterranean region will affect water availability and resource management, critically shaping the patterns of future crop production. Three companion papers analyze in detail future impacts of predicted climate change on wheat (Triticum aestivum L.) and maize (Zea mays L.) production in Spain, Greece, and Egypt, and test farm- level adaptation strategies such as early planting and cultivar change with the aid of dynamic crop models. Strategies to improve the assessment of the potential effects of future climate change on agricultural production are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:MITI.0000018269.58736.82
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  • 4
    Electronic Resource
    Electronic Resource
    Impacts of global climate change on Mediterranean agrigulture: Current methodologies and future directions (1997)
    Springer
    Mitigation and adaptation strategies for global change 1 (1997), S. 219-232 
    Details
    ISSN: 1573-1596
    Keywords: climate change ; mediterranean region ; agriculture ; cereal production ; impact assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract Current trends in Mediterranean agriculture reveal differences between the Northern and Southern Mediterranean countries as related to population growth, land and water use, and food supply and demand. The changes in temperature and precipitation predicted by general circulation models for the Mediterranean region will affect water availability and resource management, critically shaping the patterns of future crop production. Three companion papers analyze in detail future impacts of predicted climate change on wheat (Triticum aestivum L.) and maize (Zea mays L.) production in Spain, Greece, and Egypt, and test farm- level adaptation strategies such as early planting and cultivar change with the aid of dynamic crop models. Strategies to improve the assessment of the potential effects of future climate change on agricultural production are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00517804
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  • 5
    Electronic Resource
    Electronic Resource
    Impact of Climate Change on Possible Scenarios for Egyptian Agriculture in the Future (1997)
    Springer
    Mitigation and adaptation strategies for global change 1 (1997), S. 233-250 
    Details
    ISSN: 1573-1596
    Keywords: climate change ; vulnerability ; adaptation ; agriculture ; Egypt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract If no timely measures are taken to adapt Egyptian agriculture to possible climate warming, the effects may be negative and serious. Egypt appears to be particularly vulnerable to climate change because of its dependence on the Nile River as the primary water source, its large traditional agricultural base, and its long coastline, already undergoing both intensifying development and erosion. A simulation study characterized potential yield and water use efficiency decreases on two reference crops in the main agricultural regions with possible future climatic variation, even when the beneficial effects of increased CO2 were taken into account. On-farm adaptation techniques which imply no additional cost to the agricultural system, did not compensate for the yield losses with the warmer climate or improve the crop water-use efficiency. Economic adjustments such as the improvement of the overall water-use efficiency of the agricultural system, soil drainage and conservation, land management, and crop alternatives are essential. If appropriate measures are taken, negative effects of climate change in agricultural production and other major resource sectors (water and land) may be lessened.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:MITI.0000018270.16497.39
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  • 6
    Electronic Resource
    Electronic Resource
    Impact of climate change on possible scenarios for Egyptian agriculture in the future (1997)
    Springer
    Mitigation and adaptation strategies for global change 1 (1997), S. 233-250 
    Details
    ISSN: 1573-1596
    Keywords: climate change ; vulnerability ; adaption ; agriculture ; Egypt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract If no timely measures are taken to adapt Egyptian agriculture to possible climate warming, the effects may be negative and serious. Egypt appears to be particularly vulnerable to climate change because of its dependence on the Nile River as the primary water source, its large traditional agricultural base, and its long coastline, already undergoing both intensifying development and erosion. A simulation study characterized potential yield and water use efficiency decreases on two reference crops in the main agricultural regions with possible future climatic variation, even when the beneficial effects of increased CO2 were taken into account. On-farm adaptation techniques which imply no additional cost to the agricultural system, did not compensate for the yield losses with the warmer climate or improve the crop water-use efficiency. Economic adjustments such as the improvement of the overall water-use efficiency of the agricultural system, soil drainage and conservation, land management, and crop alternatives are essential. If appropriate measures are taken, negative effects of climate change in agricultural production and other major resource sectors (water and land) may be lessened.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00517805
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  • 7
    Electronic Resource
    Electronic Resource
    Impact of climate change on maize yield in central and northern Greece: A simulation study with CERES-Maize (1997)
    Springer
    Mitigation and adaptation strategies for global change 1 (1997), S. 251-271 
    Details
    ISSN: 1573-1596
    Keywords: Greece ; maize ; climate change ; CO2 effects ; adaptation ; crop simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract The potential impacts of climate change on the phenology and yield of two maize varieties in Greece were studied. Three sites representing the central and northern agricultural regions were selected: Karditsa, Naoussa and Xanthi. The CERES-Maize model, embedded in the Decision Support System for Agrotechnology Transfer (DSSAT 3.0), was used for the crop simulations, with current and possible future management practices. Equilibrium doubled CO2 climate change scenarios were derived from the GISS, GFDL, and UKMO general circulation models (GCMs); a transient scenario was developed from the GISS GCM transient run A. These scenarios predict consistent increases in air temperature, small increases in solar radiation and precipitation changes that vary considerably over the study regions in Greece. Physiological effects of CO2 on crop growth and yield were simulated. Under present management practices, the climate change scenarios generally resulted in decreases in maize yield due to reduced duration of the growing period at all sites. Adaptation analyses showed that mitigation of climate change effects may be achieved through earlier sowing dates and the use of new maize varieties. Varieties with higher kernel-filling rates, currently restricted to the central regions, could be extended to the northern regions of Greece. In the central regions, new maize varieties with longer grain-filling periods might be needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00517806
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  • 8
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    Oxidation of methane by a biological dicopper centre (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-23
    Description: Vast world reserves of methane gas are underutilized as a feedstock for the production of liquid fuels and chemicals owing to the lack of economical and sustainable strategies for the selective oxidation of methane to methanol. Current processes to activate the strong C-H bond (104 kcal mol(-1)) in methane require high temperatures, are costly and inefficient, and produce waste. In nature, methanotrophic bacteria perform this reaction under ambient conditions using metalloenzymes called methane monooxygenases (MMOs). MMOs thus provide the optimal model for an efficient, environmentally sound catalyst. There are two types of MMO. Soluble MMO (sMMO) is expressed by several strains of methanotroph under copper-limited conditions and oxidizes methane with a well-characterized catalytic di-iron centre. Particulate MMO (pMMO) is an integral membrane metalloenzyme produced by all methanotrophs and is composed of three subunits, pmoA, pmoB and pmoC, arranged in a trimeric alpha(3)beta(3)gamma(3) complex. Despite 20 years of research and the availability of two crystal structures, the metal composition and location of the pMMO metal active site are not known. Here we show that pMMO activity is dependent on copper, not iron, and that the copper active site is located in the soluble domains of the pmoB subunit rather than within the membrane. Recombinant soluble fragments of pmoB (spmoB) bind copper and have propylene and methane oxidation activities. Disruption of each copper centre in spmoB by mutagenesis indicates that the active site is a dicopper centre. These findings help resolve the pMMO controversy and provide a promising new approach to developing environmentally friendly C-H oxidation catalysts.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999467/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999467/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balasubramanian, Ramakrishnan -- Smith, Stephen M -- Rawat, Swati -- Yatsunyk, Liliya A -- Stemmler, Timothy L -- Rosenzweig, Amy C -- DK068139/DK/NIDDK NIH HHS/ -- GM070473/GM/NIGMS NIH HHS/ -- R01 DK068139/DK/NIDDK NIH HHS/ -- R01 DK068139-05/DK/NIDDK NIH HHS/ -- R01 GM070473/GM/NIGMS NIH HHS/ -- R01 GM070473-07/GM/NIGMS NIH HHS/ -- England -- Nature. 2010 May 6;465(7294):115-9. doi: 10.1038/nature08992. Epub 2010 Apr 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20410881" target="_blank"〉PubMed〈/a〉
    Keywords: Catalytic Domain ; Copper/*chemistry ; Methane/*metabolism ; Methanol/chemistry ; Methylococcus capsulatus/*enzymology ; Methylosinus trichosporium/enzymology ; *Models, Molecular ; Mutation ; Oxidation-Reduction ; Oxygenases/*chemistry/genetics/metabolism ; Protein Structure, Tertiary
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Structural basis for activation of class Ib ribonucleotide reductase (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-07
    Description: The class Ib ribonucleotide reductase of Escherichia coli can initiate reduction of nucleotides to deoxynucleotides with either a Mn(III)2-tyrosyl radical (Y*) or a Fe(III)2-Y* cofactor in the NrdF subunit. Whereas Fe(III)2-Y* can self-assemble from Fe(II)2-NrdF and O2, activation of Mn(II)2-NrdF requires a reduced flavoprotein, NrdI, proposed to form the oxidant for cofactor assembly by reduction of O2. The crystal structures reported here of E. coli Mn(II)2-NrdF and Fe(II)2-NrdF reveal different coordination environments, suggesting distinct initial binding sites for the oxidants during cofactor activation. In the structures of Mn(II)2-NrdF in complex with reduced and oxidized NrdI, a continuous channel connects the NrdI flavin cofactor to the NrdF Mn(II)2 active site. Crystallographic detection of a putative peroxide in this channel supports the proposed mechanism of Mn(III)2-Y* cofactor assembly.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020666/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020666/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boal, Amie K -- Cotruvo, Joseph A Jr -- Stubbe, JoAnne -- Rosenzweig, Amy C -- GM58518/GM/NIGMS NIH HHS/ -- GM81393/GM/NIGMS NIH HHS/ -- R01 GM058518/GM/NIGMS NIH HHS/ -- R01 GM058518-13/GM/NIGMS NIH HHS/ -- Y1-CO-1020/CO/NCI NIH HHS/ -- Y1-GM-1104/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Sep 17;329(5998):1526-30. doi: 10.1126/science.1190187. Epub 2010 Aug 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20688982" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Catalytic Domain ; Coenzymes/chemistry/metabolism ; Crystallography, X-Ray ; Enzyme Activation ; Escherichia coli/*enzymology ; Escherichia coli Proteins/*chemistry/*metabolism ; Ferrous Compounds/chemistry/metabolism ; Flavin Mononucleotide/chemistry/metabolism ; Flavodoxin/*chemistry/metabolism ; Hydrogen Bonding ; Ligands ; Manganese/*chemistry/metabolism ; Models, Molecular ; Oxidants/chemistry/metabolism ; Oxidation-Reduction ; Oxygen/chemistry/metabolism ; Peroxides/chemistry/metabolism ; Protein Folding ; Protein Multimerization ; Protein Subunits/chemistry/metabolism ; Ribonucleotide Reductases/*chemistry/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Structural basis for methyl transfer by a radical SAM enzyme (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-30
    Description: The radical S-adenosyl-L-methionine (SAM) enzymes RlmN and Cfr methylate 23S ribosomal RNA, modifying the C2 or C8 position of adenosine 2503. The methyl groups are installed by a two-step sequence involving initial methylation of a conserved Cys residue (RlmN Cys(355)) by SAM. Methyl transfer to the substrate requires reductive cleavage of a second equivalent of SAM. Crystal structures of RlmN and RlmN with SAM show that a single molecule of SAM coordinates the [4Fe-4S] cluster. Residue Cys(355) is S-methylated and located proximal to the SAM methyl group, suggesting the SAM that is involved in the initial methyl transfer binds at the same site. Thus, RlmN accomplishes its complex reaction with structural economy, harnessing the two most important reactivities of SAM within a single site.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506250/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506250/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boal, Amie K -- Grove, Tyler L -- McLaughlin, Monica I -- Yennawar, Neela H -- Booker, Squire J -- Rosenzweig, Amy C -- GM58518/GM/NIGMS NIH HHS/ -- GM63847/GM/NIGMS NIH HHS/ -- K99 GM100011/GM/NIGMS NIH HHS/ -- R01 GM058518/GM/NIGMS NIH HHS/ -- R01 GM063847/GM/NIGMS NIH HHS/ -- Y1-CO-1020/CO/NCI NIH HHS/ -- Y1-GM-1104/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 May 27;332(6033):1089-92. doi: 10.1126/science.1205358. Epub 2011 Apr 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21527678" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Proteins/chemistry/metabolism ; Catalytic Domain ; Crystallography, X-Ray ; Cysteine/chemistry ; Escherichia coli/enzymology/growth & development ; Escherichia coli Proteins/*chemistry/*metabolism ; Evolution, Molecular ; Hydrogen Bonding ; Methylation ; Methyltransferases/*chemistry/*metabolism ; Models, Molecular ; Oxidation-Reduction ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; RNA, Bacterial/metabolism ; RNA, Ribosomal, 23S/metabolism ; S-Adenosylmethionine/*chemistry/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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