ISSN:
0170-2041
Schlagwort(e):
Antitumor agents
;
Oxaziridines
;
Aldimines, unsaturated
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
A convenient method for the synthesis of previously unknown oxaziridines having unsaturated substituents at the 3-position (3a-k) is based on the selective oxidation of the imino group of α,β-unsaturated aldimines 2 with m-chloroperbenzoic acid. The title compounds and 2-tert-butyl-3-(phenylethynyl)oxaziridine (3k) exhibit potent activity against experimental tumor cells in vitro.
Zusätzliches Material:
4 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/jlac.199019900187
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