ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1573-904X
    Keywords: transdermal ; iontophoresis ; prodrug ; DHEA ; skin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. The aim of this work was to synthesize ionized dehydroepiandrosterone (DHEA) prodrugs with higher water solubility, useful for iontophoretic transdermal application. Methods. The synthesized derivatives were characterized and tested for sensitivity to chemical and enzymatic hydrolysis. Solid state and solution stability was also determined. Transdermal iontophoretic anodal transport in vitro was studied using excised rabbit skin. Results. Two DHEA ionized prodrugs were synthesized: PRO1, a primary amine derivative, and PRO2, a quaternary ammonium salt. The two derivatives possess higher water solubility and lower octanol/saline partition coefficients than DHEA. Prodrugs were sensitive to enzymatic hydrolysis; in particular the primary amine was hydrolyzed faster than the quaternary salt by esterase from porcine liver in vitro. Transdermal flux of the two prodrugs was slightly higher than the parent drug. In the case of passive diffusion, only DHEA was found in the receptor compartment, indicating the complete breakdown of the prodrug in the skin. Current application gave higher drug flux and a significant amount of prodrug was found in the receptor. Conclusions. The use of ionized prodrugs of DHEA can increase the flux attainable during transdermal anodal iontophoresis by up to 7 times, but they are useful for passive transport as well.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-0819
    Keywords: Key words Stromboli ; Neostromboli ; Orthocumulates ; Monzonites ; Magma chamber processes ; Geothermobarometry ; Flank collapse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  We describe texture, mineralogy and whole-rock composition of cognate monzonite sub-volcanic clasts within debris flow deposits related to the 5000 years catastrophic phreatomagmatic eruption probably linked to the Sciara del Fuoco sector collapse. The debris flows are at the top of accretionary lapilli-rich ash deposits overlying potassic (KS, shoshonites) lavas of the Neostromboli period. The monzonites are inferred to be crystallized in situ, at low P, at the side walls and/or roof margins of a shallow magma chamber and to be cogenetic with the KS Neostromboli extrusives. They can be considered "ideal orthocumulates" since they approximately retain a bulk liquid composition and possibly represent "slowly cooled equivalents" of their KS shoshonite host rock. The "closure temperature" of final solidification of the monzonite lithic suite was estimated through ternary-feldspar geothermobarometry, plagioclase–K-feldspar and K-feldspar–biotite equilibria and is in the range of 750–790  °C with a maximum –logfO2 around 15.1–15.3. The estimated pressure of crystallization is 〈0.5 kbar. Potassic lavas and dikes, previously emplaced during the Neostromboli period, also resemble the monzonites in both major trace elements and mineral chemistry. The cogenetic relationship between KS Neostromboli extrusives and the monzonite host-rock magma from which the sub-volcanic clasts were derived is clear evidence that a shallow magma chamber existed between the caldera collapse of the Vancori period and the Sciara del Fuoco sector collapse (i.e. between 13 000 and 5000 years). The monzonite clasts were derived from crystallization at very shallow depth (ca. 1 km) and strongly support the hypothesis of violent decompression of the shallow magmatic plumbing system during the Sciara del Fuoco sector collapse. Climax of the regressive landslide event, with maximum disruption of the chamber walls, took place during emplacement of the debris flows, i.e. during the late stage of the Neostromboli phreatomagmatic eruption.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...