ISSN:
0268-2605
Keywords:
Bis(ferrocenylalkyl)azolium cations
;
experimental tumors
;
virus-induced Rauscher leukemia
;
cytotoxicity
;
antitumor effect
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
On the basis of an earlier model of chemical carcinogenesis, the antitumor activity of the mono-, bi- and poly-nuclear ferrocene derivatives ferricenium tri-iodide (1), ferricenium tetrachloroferrate (2), 1, 1′-diethylferricenium triiodide: (3), N-(ferrocenylmethyl)hexamethylenetetramine tetrafluoroborate (4), bis(ferrocenylmethyl)benzotriazolium tetrafluoroborate (5), bis(ferrocenyl-α-ethyl)benzotriazolium tetrafluoroborate (6) and bis(ferrocenylmethyl)-2-methylbenzimidazolium tetrafluoroborate (7), and the oligomer ( - Fc - CH2 - Fc+· - CH2 - )7-8- (PF6)7-8 (8) was studied in vivo (Fc=C10H8Fe). The tumor models studied included MCH-11 (mouse sarcoma induced by methylcholantrene), P-815 (mouse mastocytoma of DBA/2 origin) and virus-induced Raucher leukemia (RLV). The cytotoxic effects of these preparations were examined against in vitro cultured normal murine cells (line L-929). The binuclear ferrocene derivatives 5, 6 and 7 inhibited the development of experimental tumors in mice. Ferricenium tri-iodide (1) was effective in Rauscher leukemia. Kinetic dependencies for most complexes had a two-phase character: the region of inhibition of tumorogenesis was followed by a region in which the complexes accelerated the development of this process. The link between the structure of compounds 1-8 and their antitumor effects is discussed.
Additional Material:
12 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aoc.590070203
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