ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Chiral stationary phase
;
Optical resolution of drugs
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The synthesis of optically pure (S,S)-N-3,5-dinitrobenzoyl-1,2-diphenylethane-1,2-diamine (DNB-DPE-DA) immobilized via an undecenoyl spacer onto silica gel and the resolving power of this new chiral stationary phase (CSP) for normal phase HPLC are described. The phase shows good enantioselectivity for various chiral compounds containing amide (imide) functionality and π-donor type aromatic subsitutents, and also for some alcohols and sulfoxides. The influence of protic and nonprotic mobile phase components on the enantioselectivity has also been examined.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02319716
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