ISSN:
1612-1112
Keywords:
Gas chromatography
;
MSD, ECD and NPD
;
Non-steroidal anti-inflammatory drugs (NSAIDs)
;
Plasma samples
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The aim of this work was to compare the performance of the MSD, ECD and NPD systems when used for drug assay in biological fluids. As a practical test, six non steroidal anti-inflammatory drugs added to plasma samples were detected and quantified. The analyses were carried out after solvent extraction from an acidic medium and subsequent methylation. The linearity of response was tested for all the detection systems in the range of 1 to 25 ng/ml. Precision and accuracy were determined at 1, 5 and 10 ng/ml. The minimum quantifiable level for the six drugs was about 1 ng/ml with each of the three detection systems.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02274495
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