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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 142 (1973), S. 329-345 
    ISSN: 1432-0878
    Keywords: Neurosecretion ; Midbrain ; Cyclostomata ; Lamprey, female ; Light- and electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Im Torus semicircularis des Mittelhirns der Neunaugen lassen sich sekretorische Neurone nachweisen. Das mesenzephale neurosekretorische Zentrum entwickelt sich erst nach der Metamorphose und ist nur bei den weiblichen Tieren ausgebildet. Das Neurosekret ist ein zystinreiches Protein und läßt sich im histologischen Schnittpräparat mit allen Methoden, die zum Nachweis peptiderger Neurosekretion im Hypothalamus verwendet werden, darstellen. Produktions- und Speicherorte des Neurosekrets sind erweiterte Zisternen des rauhen endoplasmatischen Retikulums. Es existieren keine speziellen Speicherorganellen in Form der bekannten runden, einheitlich elektronendichten Elementargranula oder in Form von dense-core Vesikeln. Speicherzisternen konnten auch in den Fortsätzen der neurosekretorischen Zellen nachgewiesen werden.
    Notes: Summary In the torus semicircularis of the midbrain of lampreys a neurosecretory area was found. The mesencephalic neurosecretory nucleus develops not earlier than after metamorphosis and is only present in females. The neurosecretory material could be determined as a cystine-rich protein demonstrable in slices, with all of the methods, that are employed for the demonstration of hypothalamic neurosecretion. The neurosecretion is produced and stored in dilatated cisterns of the rough endoplasmic reticulum. No specialized storing vesicles in the form of the well-known spherical, uniformly electron-dense elementary vesicles or dense-core vesicles are present. The storing cisterns could also be demonstrated in the processes of the neurosecretory cells.
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  • 2
    ISSN: 1432-0878
    Keywords: Neurosecretion ; Hypothalamo-hindbrain pathway ; Rat ; Blood pressure ; Milk ejection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary 1. In lactating rats and in rats deprived of water, the amount of neurosecretory material in the fibres of the neurosecretory hypothalamohindbrain pathway exceeds that in untreated control animals. Under these experimental conditions the pathway and its target regions can be well analysed by means of fluorescence and electron microscopic methods. 2. The axons belonging to the hypothalamo-hindbrain pathway originate from perikarya located in the caudal portion of the nucleus paraventricularis and also from a small group of perikarya in the caudo-lateral hypothalamus. On the way to the hindbrain the neurosecretory fibres join other fibre bundles of the mid- and hindbrain. 3. In the hindbrain most of the neurosecretory fibres terminate in the area of the nucleus tractus solitarii and in the area of the dorsal column nuclei. The axon terminals form synapses with other neurones. 4. Using cytochemical methods at the ultrastructural level (Naumann and Sterba, 1976), the authors were able to prove that the vesicles in the exohypothalamic fibres and in their synaptic terminals contain the same sort of material as the neurophysin vesicles in the posterior lobe of the hypophysis. 5. The most distinct increase in neurophysin was observed in lactating females which were separated from their sucklings after a normal lactation period of 15 days and killed four days thereafter, and in rats deprived of water for different time periods. 6. The relationship of the neurosecretory hypothalamo-hindbrain pathway to the nucleus tractus solitarii and to the dorsal column nuclei suggests that, functionally, there may be a correlation between the system of blood-pressure control and the milk ejection reflex.
    Type of Medium: Electronic Resource
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