Publication Date:
2005-06-18
Description:
Hippocampal place cells are a model system of how the brain constructs cognitive representations and of how these representations support complex behavior, learning, and memory. There is, however, a lack of detailed knowledge about the properties of hippocampal afferents. We recorded multiple single units from the hippocampus and the medial and lateral entorhinal areas of behaving rats. Although many medial entorhinal neurons had highly specific place fields, lateral entorhinal neurons displayed weak spatial specificity. This finding demonstrates a fundamental dissociation between the information conveyed to the hippocampus by its major input streams, with spatial information represented by the medial and nonspatial information represented by the lateral entorhinal cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hargreaves, Eric L -- Rao, Geeta -- Lee, Inah -- Knierim, James J -- K02 MH63297/MH/NIMH NIH HHS/ -- R01 NS039456/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1792-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, Post Office Box 20708, University of Texas Medical School at Houston, Houston, TX 77225, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15961670" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Behavior, Animal
;
Brain Mapping
;
Cues
;
Electrodes, Implanted
;
Entorhinal Cortex/*physiology
;
Hippocampus/*physiology
;
Learning/*physiology
;
Male
;
Neural Pathways
;
Neurons/*physiology
;
Pyramidal Cells/physiology
;
Rats
;
Rats, Long-Evans
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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