Publication Date:
2008-10-17
Description:
Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to genetic alterations, but identifying the genes responsible has proved challenging. Microarray experiments have now revealed abundant copy-number variation--a type of variation in which stretches of DNA are duplicated, deleted and sometimes rearranged--in the human population. Genes affected by copy-number variation are good candidates for research into disease susceptibility. The complexity of neuropsychiatric genetics, however, dictates that assessment of the biomedical relevance of copy-number variants and the genes that they affect needs to be considered in an integrated context.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, Edwin H Jr -- Scherer, Stephen W -- HD055751/HD/NICHD NIH HHS/ -- England -- Nature. 2008 Oct 16;455(7215):919-23. doi: 10.1038/nature07458.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Juvenile Research, Department of Psychiatry, University of Illinois, 1747 West Roosevelt Road, Chicago, Illinois 60608, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18923514" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Autistic Disorder/genetics
;
Gene Dosage/*genetics
;
Genetic Predisposition to Disease/genetics
;
Genomics
;
Humans
;
Mental Disorders/*genetics
;
Nervous System Diseases/*genetics
;
Schizophrenia/genetics
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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