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  • Antibodies, Monoclonal/*immunology/therapeutic use  (1)
  • NIDDM  (1)
  • 1985-1989  (2)
  • 1
    Electronic Resource
    Electronic Resource
    The influence of glipizide on early insulin release and glucose disposal before and after dietary regulation in diabetic patients with different degrees of hyperglycaemia (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 31-37 
    Details
    ISSN: 1432-1041
    Keywords: glipizide ; diabetes mellitus ; NIDDM ; insulin release ; glucose disposal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary An early defect in subjects with non-insulin-dependent diabetes mellitus (NIDDM) and the preceding phase of impaired glucose tolerance (IGT) is a reduction in early insulin release and hence a prolonged elevation of postprandial blood glucose. We therefore assessed whether a rapidly acting sulphonylurea (glipizide 5 mg 0.5 h before a test meal) could correct these disturbances in 38 IGT/NIDDM subjects, whose early insulin release and postprandial blood glucose elevations remained unimproved after 10 weeks of dietary regulation. We also assessed whether the efficacy of glipizide was dependent upon the ambient blood glucose concentration, and if early systemic availability of the drug was important for the blood glucose lowering effect. A single dose of glipizide normalized early insulin release and hence reduced the postprandial blood glucose increase that was not lowered by dietary regulation. The efficacy of glipizide was dependent upon the early systemic availability of the drug, but early systemic availability and efficacy were independent of the extent of blood glucose elevation, at least within a range of 6–12 mmol·l−1 of fasting blood glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00555504
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Human monoclonal antibodies to Pf 155, a major antigen of malaria parasite Plasmodium falciparum (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-03
    Description: Pf 155, a protein of the human malaria parasite Plasmodium falciparum, is strongly immunogenic in humans and is believed to be a prime candidate for the preparation of a vaccine. Human monoclonal antibodies to Pf 155 were obtained by cloning B cells that had been prepared from an immune donor and transformed with Epstein-Barr virus. When examined by indirect immunofluorescence, these antibodies stained the surface of infected erythrocytes, free merozoites, segmented schizonts, and gametocytes. They bound to a major polypeptide with a relative molecular weight of 155K and to two minor ones (135K and 120K), all having high affinity for human glycophorin. The antibodies strongly inhibited merozoite reinvasion in vitro, suggesting that they might be appropriate reagents for therapeutic administration in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Udomsangpetch, R -- Lundgren, K -- Berzins, K -- Wahlin, B -- Perlmann, H -- Troye-Blomberg, M -- Carlsson, J -- Wahlgren, M -- Perlmann, P -- Bjorkman, A -- New York, N.Y. -- Science. 1986 Jan 3;231(4733):57-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3510452" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology/therapeutic use ; Antigens, Protozoan/analysis/*immunology ; Humans ; Plasmodium falciparum/*immunology ; Vaccines/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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