ISSN:
1573-3904
Keywords:
Urethane
;
N-protected carboxyanhydrides (UNCAs)
;
N-protected N-acyl amino acids
;
N-Acylation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The reactivity of Grignard reagents with UNCAs (UrethaneN-protected Carboxyanhydrides of Amino acids)is described. We observed that, depending on the method ofaddition of the organometallic compounds, the reactionproceeded differently:(i) when the UNCA was added to the Grignard reagent, weobtained a mixture of five different products whichwere all identified; and (ii) when the organometallic reagent was added to theUNCA, we also obtained a mixture of the same productsbut in different proportions, with the major componentcorresponding to the urethane N-protected N-acyl aminoacid derivative.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008811813871
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