ISSN:
1573-3904
Keywords:
Urethane N-protected carboxyanhydrides (UNCAs)
;
N-ProtectedN-acyl amino acids
;
N-Acylation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The reactivity of Grignard reagents with UNCAs (Urethane N-protected Carboxyanhydrides of Amino acids) is described. We observed that, depending on the method of addition of the organometallic compounds, the reaction proceeded differently: (i) when the UNCA was added to the Grignard reagent, we obtained a mixture of five different products which were all identified; and (ii) when the organometallic reagent was added to the UNCA, we also obtained a mixture of the same products but in different proportions, with the major component corresponding to the urethane N-protectedN-acyl amino acid derivative.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02442883
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