Publication Date:
2000-03-17
Description:
Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6, was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Odom, A R -- Stahlberg, A -- Wente, S R -- York, J D -- New York, N.Y. -- Science. 2000 Mar 17;287(5460):2026-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Pharmacology and Cancer Biology and of Biochemistry, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10720331" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Arginine/metabolism
;
Cell Nucleus/enzymology/*metabolism
;
DNA-Binding Proteins/metabolism
;
*Gene Expression Regulation, Fungal
;
Inositol 1,4,5-Trisphosphate/metabolism
;
Inositol Phosphates/*metabolism
;
Minichromosome Maintenance 1 Protein
;
Molecular Sequence Data
;
Phosphoric Monoester Hydrolases/metabolism
;
Phosphorylation
;
Phosphotransferases (Alcohol Group Acceptor)/chemistry/*metabolism
;
Phytic Acid/metabolism
;
Saccharomyces cerevisiae/enzymology/*genetics
;
Signal Transduction
;
Transcription Factors/metabolism
;
*Transcription, Genetic
;
Type C Phospholipases/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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