Publication Date:
2011-01-29
Description:
The human gut is colonized with a wide variety of microorganisms, including species, such as those belonging to the bacterial genus Bifidobacterium, that have beneficial effects on human physiology and pathology. Among the most distinctive benefits of bifidobacteria are modulation of host defence responses and protection against infectious diseases. Nevertheless, the molecular mechanisms underlying these effects have barely been elucidated. To investigate these mechanisms, we used mice associated with certain bifidobacterial strains and a simplified model of lethal infection with enterohaemorrhagic Escherichia coli O157:H7, together with an integrated 'omics' approach. Here we show that genes encoding an ATP-binding-cassette-type carbohydrate transporter present in certain bifidobacteria contribute to protecting mice against death induced by E. coli O157:H7. We found that this effect can be attributed, at least in part, to increased production of acetate and that translocation of the E. coli O157:H7 Shiga toxin from the gut lumen to the blood was inhibited. We propose that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fukuda, Shinji -- Toh, Hidehiro -- Hase, Koji -- Oshima, Kenshiro -- Nakanishi, Yumiko -- Yoshimura, Kazutoshi -- Tobe, Toru -- Clarke, Julie M -- Topping, David L -- Suzuki, Tohru -- Taylor, Todd D -- Itoh, Kikuji -- Kikuchi, Jun -- Morita, Hidetoshi -- Hattori, Masahira -- Ohno, Hiroshi -- England -- Nature. 2011 Jan 27;469(7331):543-7. doi: 10.1038/nature09646.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21270894" target="_blank"〉PubMed〈/a〉
Keywords:
Acetates/*metabolism
;
Animals
;
Bifidobacterium/genetics/*metabolism
;
Cercopithecus aethiops
;
Escherichia coli Infections/microbiology/*prevention & control
;
Escherichia coli O157/*physiology
;
Gene Expression Profiling
;
Genome, Bacterial
;
Mice
;
Molecular Sequence Data
;
Vero Cells
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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