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Use of osmotic minipumps for delivery of parathyroid hormone (1982)

Hock, J. M. ; Simmons, H. A. ; Schiess, M. C. ; [et al.]

Springer

Calcified tissue international 34 (1982), S. 270-272

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ISSN: 1432-0827

Keywords: Parathyroid hormone ; Minipumps ; Bone resorption

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Physics

Notes: Summary To determine if osmotic minipumps can be used for the local delivery of parathyroid hormone (PTH), we examined the bone resorbing activity of PTH in minipumps, either removed and assayed in bone organ cultures or released over rat calvaria. Biological activity of PTH was maintained for up to 6 days when the hormone solution contained serum and the minipumps and tubing were siliconized and flushed with diluent prior to use. Addition of cysteine did not enhance activity.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02411249

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