Publikationsdatum:
1984-05-04
Beschreibung:
Behavioral responses to an adenosine receptor agonist and antagonist were examined in mice genetically selected for differential sensitivity to the soporific effects of ethanol. Both ethanol and the adenosine receptor agonist L-phenylisopropyladenosine had greater sedative and hypothermic effects in ethanol-sensitive "long-sleep" mice than in ethanol-insensitive "short-sleep" mice. Long-sleep mice were also more sensitive to the excitatory behavioral effects of theophylline, an adenosine receptor antagonist. These data suggest that adenosine may be an endogenous mediator of responses to ethanol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Proctor, W R -- Dunwiddie, T V -- 07043/PHS HHS/ -- 2702/PHS HHS/ -- New York, N.Y. -- Science. 1984 May 4;224(4648):519-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6324348" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Adenosine/*analogs & derivatives
;
Animals
;
Behavior, Animal/*drug effects
;
Body Temperature/drug effects
;
Dose-Response Relationship, Drug
;
Escape Reaction/drug effects
;
Ethanol/*pharmacology
;
Mice
;
Phenylisopropyladenosine/*pharmacology
;
Receptors, Cell Surface/physiology
;
Receptors, Purinergic
;
Sleep/*drug effects
;
Theophylline/*pharmacology
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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