Publication Date:
2003-11-08
Description:
Activated CD8+ T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8+ T cells. We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8+ T cells, including interferon-gamma (IFN-gamma), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8+ T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pearce, Erika L -- Mullen, Alan C -- Martins, Gislaine A -- Krawczyk, Connie M -- Hutchins, Anne S -- Zediak, Valerie P -- Banica, Monica -- DiCioccio, Catherine B -- Gross, Darrick A -- Mao, Chai-An -- Shen, Hao -- Cereb, Nezih -- Yang, Soo Y -- Lindsten, Tullia -- Rossant, Janet -- Hunter, Christopher A -- Reiner, Steven L -- AI-042370/AI/NIAID NIH HHS/ -- GM-07229/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2003 Nov 7;302(5647):1041-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14605368" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Arenaviridae Infections/immunology
;
Base Sequence
;
CD8-Positive T-Lymphocytes/*immunology/physiology
;
Cell Differentiation
;
Cytotoxicity, Immunologic
;
Gene Expression Regulation
;
Granzymes
;
Interferon-gamma/biosynthesis
;
Lymphocyte Activation
;
Lymphocytic choriomeningitis virus/immunology
;
Membrane Glycoproteins/biosynthesis/genetics
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Molecular Sequence Data
;
Perforin
;
Pore Forming Cytotoxic Proteins
;
RNA, Messenger/genetics/metabolism
;
Serine Endopeptidases/biosynthesis/genetics
;
T-Box Domain Proteins/chemistry/genetics/*physiology
;
Th2 Cells/immunology/physiology
;
Transcription Factors/chemistry/genetics/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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