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  • 1
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    Role of bacterial intimin in colonic hyperplasia and inflammation (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-27
    Description: Enteropathogenic Escherichia coli (EPEC) cells adhere to gut epithelial cells through intimin alpha: the ligand for a bacterially derived epithelial transmembrane protein called the translocated intimin receptor. Citrobacter rodentium colonizes the mouse colon in a similar fashion and uses a different intimin: intimin beta. Intimin alpha was found to costimulate submitogenic signals through the T cell receptor. Dead intimin beta+ C. rodentium, intimin alpha-transfected C. rodentium or E. coli strain K12, and EPEC induced mucosal hyperplasia identical to that caused by C. rodentium live infection, as well as a massive T helper cell-type 1 immune response in the colonic mucosa. Mutation of cysteine-937 of intimin to alanine reduced costimulatory activity in vitro and prevented immunopathology in vivo. The mucosal changes elicited by C. rodentium were interferon-gamma-dependent. Immunopathology induced by intimin enables the bacteria to promote conditions that are favorable for increased microbial colonization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Higgins, L M -- Frankel, G -- Connerton, I -- Goncalves, N S -- Dougan, G -- MacDonald, T T -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1999 Jul 23;285(5427):588-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Paediatric Gastroenterology, St. Bartholomews and the Royal London School of Medicine and Dentistry, London EC1A 7BE, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10417389" target="_blank"〉PubMed〈/a〉
    Keywords: *Adhesins, Bacterial ; Animals ; Bacterial Adhesion ; Bacterial Outer Membrane Proteins/pharmacology/*physiology ; *Carrier Proteins ; Citrobacter/*pathogenicity ; Colitis/immunology/*microbiology/pathology ; Colon/immunology/microbiology/*pathology ; Cytokines/biosynthesis/genetics ; Enterobacteriaceae Infections/immunology/*microbiology/pathology ; Escherichia coli/pathogenicity ; *Escherichia coli Proteins ; Hyperplasia ; Interferon-gamma/physiology ; Intestinal Mucosa/immunology/microbiology/pathology ; Ligands ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Receptors, Cell Surface/metabolism ; T-Lymphocytes/immunology ; Th1 Cells/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Genes for epilepsy mapped in the mouse (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-08-09
    Description: The neurological mutant mouse strain E1 is a model for complex partial seizures in humans. The inheritance of epileptic seizures with seven conventional chromosomal markers and over 60 endogenous proviral markers was studied by means of back-crosses of E1 with two seizure-resistant strains, DBA/2J and ABP/LeJ. The major gene responsible for this epileptic phenotype (El-1) was localized to a region distal with respect to the centromere on chromosome 9. At least one other gene, El-2, linked to proviral markers on chromosome 2, also influences the seizure phenotype. In addition, a potential modifier of seizures was detected in the DBA/2J background. The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rise, M L -- Frankel, W N -- Coffin, J M -- Seyfried, T N -- NS 23355/NS/NINDS NIH HHS/ -- R35CA44385/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1991 Aug 9;253(5020):669-73.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Boston College, Chestnut Hill 02167.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1871601" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; Crosses, Genetic ; Epilepsy/*genetics ; Female ; Genetic Predisposition to Disease ; Male ; Mice ; Mice, Inbred Strains ; Mice, Neurologic Mutants/*genetics ; Recombination, Genetic ; Seizures/genetics ; Software
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Drug research. Roche exits RNAi field, cuts 4800 jobs (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2010 Nov 26;330(6008):1163. doi: 10.1126/science.330.6008.1163.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21109638" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Clinical Trials as Topic ; *Drug Industry/economics/manpower ; Humans ; Personnel Downsizing ; *RNA Interference ; RNA, Small Interfering/administration & dosage/adverse effects/*therapeutic use
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Immune therapy steps up the attack (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2010 Oct 22;330(6003):440-3. doi: 10.1126/science.330.6003.440.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20966228" target="_blank"〉PubMed〈/a〉
    Keywords: Adoptive Transfer ; Antibodies, Neoplasm/immunology ; Clinical Trials as Topic ; Female ; Humans ; *Immunotherapy ; Male ; Melanoma/therapy ; Neoplasms/*therapy ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Cancer research. As questions grow, Duke halts trials, launches investigation (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2010 Aug 6;329(5992):614-5. doi: 10.1126/science.329.5992.614.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20688986" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents/pharmacology/*therapeutic use ; Biomedical Research/*standards ; Cell Line, Tumor ; Clinical Trials as Topic ; *Gene Expression Profiling ; Humans ; Neoplasms/*drug therapy/*genetics ; North Carolina ; Periodicals as Topic ; Pharmacogenetics ; Publishing ; Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Immunology. Replacing an immune system gone haywire (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-02-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2010 Feb 12;327(5967):772-4. doi: 10.1126/science.327.5967.772.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20150460" target="_blank"〉PubMed〈/a〉
    Keywords: Autoimmune Diseases/*therapy ; Clinical Trials as Topic ; *Hematopoietic Stem Cell Transplantation/adverse effects/mortality ; Humans ; Immune System/physiology ; Recurrence ; Remission Induction ; Transplantation Conditioning
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Personalized medicine. Pushing the envelope in neuroblastoma therapy (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2011 Sep 16;333(6049):1569-71. doi: 10.1126/science.333.6049.1569.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21921174" target="_blank"〉PubMed〈/a〉
    Keywords: *Algorithms ; Animals ; Antineoplastic Agents/*therapeutic use ; Child ; Child, Preschool ; Clinical Trials as Topic ; Disease Models, Animal ; Gene Expression Profiling ; Humans ; Mice ; *Molecular Targeted Therapy ; Neuroblastoma/*drug therapy/*genetics ; *Precision Medicine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Clinical studies. Trying to reset the clock on type 1 diabetes (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):819-21. doi: 10.1126/science.333.6044.819.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21835995" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/administration & dosage/adverse effects/*therapeutic use ; Antigens, CD3/*immunology ; Clinical Trials as Topic ; Diabetes Mellitus, Type 1/*drug therapy/*immunology/pathology/prevention & ; control ; Humans ; Insulin-Secreting Cells/immunology/pathology ; Mice ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Breakthrough of the year 2013. Cancer immunotherapy (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2013 Dec 20;342(6165):1432-3. doi: 10.1126/science.342.6165.1432.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24357284" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies/*therapeutic use ; Antibodies, Monoclonal/therapeutic use ; CTLA-4 Antigen/*antagonists & inhibitors/immunology ; Clinical Trials as Topic ; Humans ; Immunotherapy/*trends ; Melanoma/immunology/mortality/therapy ; Neoplasms/*immunology/mortality/*therapy ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    When mice mislead (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2013 Nov 22;342(6161):922-3, 925. doi: 10.1126/science.342.6161.922.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24264972" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation/*standards/*statistics & numerical data ; Animals ; Bias (Epidemiology) ; Double-Blind Method ; Humans ; Mice ; Random Allocation ; Sample Size
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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