ISSN:
0749-1581
Keywords:
13C NMR
;
Methadone salts
;
Methadol salts
;
Solid-state and solution conformation
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Carbon-13 NMR data for salts of methadone and methadol in the solid-state were used to elucidate the crystalline forms of the compounds and to determine if more than one conformer contributes to a single crystalline form. A comparison of 13C NMR isotropic chemical shift data for these compounds in the solid-state and in various solvents was used to correlate solution and solid-state conformations (determined from x-ray data). Three-bond 1H—13C and 1H—1H coupling constants, measured by various one- and two-dimensional NMR techniques, were compared with those calculated from x-ray dihedral angle data in order to confirm or dispute the conformational predictions based on chemical shift comparisons.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260270403
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